Clinical pathogenetic characteristics of porphyria cutanea tarda course in residents of the Krasnodar Territory

Abstract

Porphyria cutanea tarda (PCT) is a multifactorial photodermatosis with the clinical manifestations which depend on the season, insolation level, and occupational factors. Case history, clinical symptom complexes, and the total scope of laboratory data (serum iron and transaminases, urinary uroporphyrin, and fecal coproporphyrin) are analyzed for each patient with PCT, resident of the Krasnodar Territory, over the period of 2011-2013. Relationships between the relapse development, course and clinical manifestations of PCT and the season, individual features, and concomitant diseases are detected. Biochemical findings indicate high levels of serum transaminases and iron, uroporphyrins, and coproporphyrins. Improvement of the complex of diagnostic, therapeutic and preventive measures, standardization of follow-up of the patients, and cooperation of dermatovenereologists and specialists in allied fields can limit the prevalence of PCT and lead to a stable remission of the disease.

Keywords

porphyria cutanea tarda / clinical course / laboratory diagnosis

References

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