Photodynamic therapy for acne vulgaris

Abstract

Acne vulgaris remain the most prevalent disease in adolescents and young adults. Today photo therapy, specially, photodynamic therapy, is usedfor the treatment of acne. The mechanism of action of this treatment modality is based on selective destruction of cells as a result of photo-stimulated chemical reaction. Twenty patients with acne of moderate severity were treated by photodynamic therapy in combination with systemic antibacterial therapy (doxicyclin) and topical drugs (azelaic acid). Stable improvement of the skin process was attained in 86% patients. Hence, photodynamic therapy proved to be a safe and effective methodfor the treatment of acne.

Keywords

acne / pathogenesis / phototherapy / photodynamic therapy / aminolevulinic acid / methylaminolevulinate

References

[1] Майорова А.В., Шаповалов В.С., Ахтямов С.Н. Угревая болезнь в практике врача дерматокосметолога. М.: Фирма «Клавель»; 2005.

[2] Rosso J., Bikowski J., Baum E. Prevalence of truncal acne vulgaris: A population study based private practice experience. J. Am. Acad. Dermatol. 2007; 56(Suppl. 2): AB3.

[3] Адаскевич В.П., ред. Акне вульгарные и розовые. Новгород: НГМА; 2003.

[4] Самцов А.В. Акне и акнеформные дерматозы. М.: ЮТКОМ; 2009.

[5] Herane M.I., Ando I. Acnein infancy and acne genetics. J. Dermatol. 2003; 206(1): 24-8.

[6] Мордовцев В.Н., Новикова Н.Ф., Алчангян Л.В. Обыкновенные угри. Медицина для всех. 2001; 2:18-9.

[7] Самгин М.А., Монахов С.А. Акне (лекция). Российский журнал кожных и венерических болезней. 2005; 3: 55-66.

[8] Fitz-Gibbon S., Tomida S., Chiu B.H., Nguyen L., Du C., Liu M., et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J. Invest. Dermatol. 2013; 133(9): 2152-60. doi: 10.1038/jid.2013.21.

[9] Jappe U., Ingham E., Henwood J., Holland K.T. Propionibacterium acne and inflammation in acne; P acnes has T-cell mitogenic activity. Br. J. Dermatol. 2002; 146(2): 202-9.

[10] Махмудов А.В., Олисова О.Ю., Пинсон И.Я., Верхогляд И.В. Фототерапия голубым светом. Пластическая хирургия и косметология. 2010; 3: 487-90.

[11] Mercer J.B., Nielsen S.P., Hoffmann G. Improvement of wound healing by water-filtered infrared-A (wIRA) in patients with chronic venous stasis ulcers of the lower legs including evaluation using infrared thermography. Ger. Med. Sci. 2008; 6: Doc11.

[12] Elman M., Slatkine M., Harth Y. The effective treatment of acne vulgaris by high-intensity, narrow-band 405-420 nm light source. J. Cosmet. Laser Ther. 2003; 5(2): 111-7.

[13] Kawada А., Aragane Y., Kameyama H., Sangen Y., Tezuka T. Acne phototherapy with a high-intensity, enhanced, narrowband, blue light source: an open study and in vitro investigation. J. Dermatol. Sci. 2002; 30: 129-35.

[14] Голдман М.П., ред. Фотодинамическая терапия. М.: Рид Элсивер; 2010.

[15] Ahmad N., Mukhtar H. Mechanism of photodynamic therapyinduced cell death. Methods Enzymol. 2000; 319: 342-58.

[16] Alster T.S., Tanzi E.L. Photodynamic therapy with topical aminolevulinic acid and pulsed dye laser irradiation for sebaceous hyperplasia. J. Drugs Dermatol. 2003; 2(5): 501-4.

[17] Iton Y., Ninomiya Y., Tajima S., Ishibashi A. Photodynamic therapy of acne vulgaris with topical delta-aminolaevulinic acid and incoherent light in Japanese patients. Br. J. Dermatol. 2001; 144(3): 575-9.

RIGHTS & PERMISSIONS

Eco-Vector