Modern aspects of effective therapy acne vulgaris

Abstract

Today the diagnosis of acne severity is not limited by evaluation of clinical manifestations only. Therefore, indications for isotretinoin therapy of the dermatosis have been extended. We evaluated the efficiency and safety of Sotret in therapy of 30 patients with severe acne and with acne resistant to other therapies. Of these, 19 patients (63.33%) presented with mild-severety and 11 (36.67%) with severe condition. The acne dermatological index (ADI) and CADI score were evaluated and biochemical and clinical blood analyses were carried out in all patients. Sotret monotherapy was carried out. The clinical remission was attained in 28 (93.33%), and slight amelioration in 2 (6.67%) patients. Sotret therapy proved to be highly effective and was well tolerated.

Keywords

acne / severity / course / resistance / isotretinoin / Sotret / efficiency

References

[1] Zouboulis C.C., Piquero-Martin J. Update and future of systemic acne treatment. Dermatology. 2003; 206(1): 37-53.

[2] Thiboutot D., Gollnick H., Bettoli V., Dreno B., Kang S., Leyden J.J., et al.; Global Alliance to Improve Outcomes in Acne. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J. Am. Acad. Dermatol. 2009; 60(5, Suppl):S1-50. doi: 10.1016/j.jaad.2009.01.019.

[3] Gollnick H., Cunliffe W., Berson D., Dreno B., Finlay A., Leyden J.J., et al.; Global Alliance to Improve Outcomes in Acne. Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J. Am. Acad. Dermatol. 2003; 49(1, Suppl.): S1-37.

[4] Перламутров Ю.Н., Ольховская К.Б. Клинико-психологические отклонения у больных акне и методы их коррекции. Клиническая дерматология и венерология. 2012; 4: 70-2.

[5] Nast A., Dreno B., Bettoli V., Degitz K., Erdmann R., Finlay A.Y, et al.; European Dermatology Forum. European evidence-based (S3) guidelines for the treatment of acne. J. Eur. Acad. Dermatol. Venereol. 2012; 26 (Suppl. 1): 1-29. doi: 10.1111/j.1468-3083.2011.04374.x.

[6] Санакоева Э.Т., Масюкова С.А., Ильина И.В., Введенская Э.В., Плиева Д.В., Алиева П.М., Мамашева Г.Д. Современная терапия акне и акнеформных дерматозов. Российский журнал кожных и венерических болезней. 2013; 6: 37-42.

[7] Layton A.M. Disorders of the sebaceous glands. In: Burns T., Breathnach S., Cosx N., Griffiths C., eds. Rooks Textbook of Dermatology. Oxford: Wiley-Blackwell; 2010: 38-9.

[8] Dreno B., Alirezai M., Auffret N., Beylot C., Chivot M., Daniel F., et al. Clinical and psychological correlation in acne: use of the ECLA and CADI scales. Ann. Dermatol. Venereol. 2007; 134(5, Pt 1): 451-5.

[9] Layton A.M., Dreno B., Gollnick H.P., Zouboulis C.C. A review of the European Directive for prescribing systemic isotretinoin for acne vulgaris. J. Eur. Acad. Dermatol. Venereol. 2006; 20(7): 773-6.

[10] Tan J.K., Tang J., Fung K., Gupta A.K., Thomas D.R., Sapra S., et al. Development and validation of a comprehensive acne severity scale. J. Cutan. Med. Surg. 2007; 11(6): 211-6.

[11] Akman A., Durusoy C., Senturk M., Koc C.K., Soyturk D., Alpsoy E. Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. Arch. Dermatol. Res. 2007; 299(10): 467-73.

[12] Zane L.T., Leyden W.A., Marqueling A.L., Manos M.M. A population-based analysis of laboratory abnormalities during isotretinoin therapy for acne vulgaris. Arch. Dermatol. 2006; 142(8): 1016-22.

[13] Bettoli V., Borghi А., Zauli S., Toni G., Ricci M., Giari S., Virgili A. Maintenance therapy for acne vulgaris: efficacy of a 12-month treatment with adapalene-benzoyl peroxide after oral isotretinoin and a review of the literature. Dermatology. 2013; 227(2): 97-102. doi: 10.1159/000350820.

[14] Center for drug evaluation and research. Appl. No 76-041. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/076041.pdf

[15] Кочергин Н.А., Самгин М.А., Монахов С.А., Игнатьев Д. Дерматологический индекс акне. Эстетическая медицина. 2004; 3(1): 62-5.

[16] Motley R.J., Finlay A.Y. Practical use of a disability index in the routine management of acne. Clin. Exp. Dermatol. 1992; 17(1): 1-3.

RIGHTS & PERMISSIONS

Eco-Vector