Cytomegalovirus infection of the urogenital tract in women

Abstract

The number of sexually active women with chronic inflammatory diseases of pelvic organ has increased recently. Cytomegalovirus (CMV) is detected in scrapings off the cervix uteri and endometrium of these patients. We studied the forms of CMV infection in sexually active women of reproductive age. A total of356patients were observed. The CMV infection was studied by enzyme immunoassay for detection of specific serum anti-CMV IgM (qualitative analysis) and IgG. Virological isolation of CMV from the blood, saliva, urine, cervical and vaginal discharge was carried out on human embryo lung fibroblast culture. Indirectfluorescent test for detection of CMV antigen was carried out with monoclonal antibodies to pre-early (pp27) and early (pp65) antigens. The CMV DNA was detected by polymerase chain reaction. Opportunistic and pathogenic urogenital flora was detected by the common methods: microscopic, bacteriological, and molecular genetic. The basic clinical laboratory characteristics of various forms of urogenital CMV infection were identified; this will promote optimization of the diagnosis and therapeutic strategy in this category ofpatients. Combined therapy including panavir in patients with latent and reactivated CMV infection was highly effective.

Keywords

cytomegalovirus infection / urogenital tract / clinical characteristics / panavir / antiviral activity

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