Studies of lichen planus pathomorphosis by evaluating its modern histological signs
V. V Barbinov , V. S Chirsky , G. N Tarasenko , D. V Barbinov
Russian Journal of Skin and Venereal Diseases ›› 2014, Vol. 17 ›› Issue (3) : 42 -48.
Studies of lichen planus pathomorphosis by evaluating its modern histological signs
Statistically significant histological models of lichen planus (LP) were detected by comparing histological preparations from 102 patients with the final diagnosis of LP, analyzed using a Histoderm expert system, with the final clinical diagnosis in this sample, after preliminary analysis (by the same expert system) of more than 600 histological symptoms vs. 224 other dermatoses presented in this system. Comparison of the results of two studies showed that of the symptoms determining various dermatoses, 49 were statistically significant for the diagnosis of LP, corresponding to its 6 histological models. Only 22 symptoms, characterizing only 2 of the probable histological models, were significant in skin biopsy specimens from our sample ofpatients with LP. The results indicated the LP pathomorphosis and indirectly confirmed the immunoallergic hypothesis of its pathogenesis.
lichen planus / histological models of inflammatory dermatoses / expert systems / Histoderm
Eco-Vector
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