HIGH CONCENTRATION OF 3β-HYDROXYSTEROID DEHYDROGENASE IN SKIN CELLS OF PATIENTS WITH ACNE VULGARIS
A. N Bagrets , V. A Kuznetsov , T. G Ruksha
Russian Journal of Skin and Venereal Diseases ›› 2013, Vol. 16 ›› Issue (5) : 62 -64.
HIGH CONCENTRATION OF 3β-HYDROXYSTEROID DEHYDROGENASE IN SKIN CELLS OF PATIENTS WITH ACNE VULGARIS
The synthesis of testosterone is catalyzed by 3β-hydroxysteroid dehydrogenase. The development of acne is partialy associated with androgen-mediated hyperplasia of the sebaceous glands. The distribution and concentrations of 3β-hydroxysteroid dehydrogenase in the skin were studied in patients with acne. The results indicated hyperexpression of 3β-hydroxysteroid dehydrogenase in sebocytes, this presumably indicating disorders of the steroid metabolism in acne skin.
acne vulgaris / proliferating cell nuclear antigen / 3b-hydroxysteroid dehydrogenase / steroidogenesis
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