HIGH CONCENTRATION OF 3β-HYDROXYSTEROID DEHYDROGENASE IN SKIN CELLS OF PATIENTS WITH ACNE VULGARIS

A. N Bagrets; V. A Kuznetsov; T. G Ruksha

doi:10.17816/dv36884

Russian Journal of Skin and Venereal Diseases ›› 2013, Vol. 16 ›› Issue (5) : 62 -64. DOI: 10.17816/dv36884

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HIGH CONCENTRATION OF 3β-HYDROXYSTEROID DEHYDROGENASE IN SKIN CELLS OF PATIENTS WITH ACNE VULGARIS

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Abstract

The synthesis of testosterone is catalyzed by 3β-hydroxysteroid dehydrogenase. The development of acne is partialy associated with androgen-mediated hyperplasia of the sebaceous glands. The distribution and concentrations of 3β-hydroxysteroid dehydrogenase in the skin were studied in patients with acne. The results indicated hyperexpression of 3β-hydroxysteroid dehydrogenase in sebocytes, this presumably indicating disorders of the steroid metabolism in acne skin.

Keywords

acne vulgaris / proliferating cell nuclear antigen / 3b-hydroxysteroid dehydrogenase / steroidogenesis

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A. N Bagrets, V. A Kuznetsov, T. G Ruksha. HIGH CONCENTRATION OF 3β-HYDROXYSTEROID DEHYDROGENASE IN SKIN CELLS OF PATIENTS WITH ACNE VULGARIS. Russian Journal of Skin and Venereal Diseases, 2013, 16(5): 62-64 DOI:10.17816/dv36884