HIGH CONCENTRATION OF 3β-HYDROXYSTEROID DEHYDROGENASE IN SKIN CELLS OF PATIENTS WITH ACNE VULGARIS

Abstract

The synthesis of testosterone is catalyzed by 3β-hydroxysteroid dehydrogenase. The development of acne is partialy associated with androgen-mediated hyperplasia of the sebaceous glands. The distribution and concentrations of 3β-hydroxysteroid dehydrogenase in the skin were studied in patients with acne. The results indicated hyperexpression of 3β-hydroxysteroid dehydrogenase in sebocytes, this presumably indicating disorders of the steroid metabolism in acne skin.

Keywords

acne vulgaris / proliferating cell nuclear antigen / 3b-hydroxysteroid dehydrogenase / steroidogenesis

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