SUPPRESSIVE EFFECTS OF PSORALENE PHOTO-OXIDATION PRODUCTS ON CONTACT SENSITIVITY REACTION IN MICE: LYMPHOCYTE PROLIFERATION INHIBITION AND APOPTOSIS INDUCTION
Ilya Alekseevich Pyatnitsky , Svetlana Ivanovna Pavlova , Diana Zaurbekovna Albegova , Ivan Genrihovich Kozlov , Aleksandr Yakovlevich Potapenko , Alla Anatolievna Kyagova
Russian Journal of Skin and Venereal Diseases ›› 2013, Vol. 16 ›› Issue (6) : 59 -63.
SUPPRESSIVE EFFECTS OF PSORALENE PHOTO-OXIDATION PRODUCTS ON CONTACT SENSITIVITY REACTION IN MICE: LYMPHOCYTE PROLIFERATION INHIBITION AND APOPTOSIS INDUCTION
The effects of psoralene photo-oxidation products (PPP) on 2,4-dinitrofluorobenzene (DNFB) contact sensi tivity of mice were studied. Injections of PPP to DNFB-sensitized mice led to a decrease in the cell counts in the regional lymph nodes and to reduction of the cellular proliferative activity. Proliferation reduction was paralleled by changes in the lymph node cell cytokine balance: lesser production of IL-2, IL-4, and INF-γ and higher production of IL-17. Interestingly that PPP did not change the production of IL-10 and IL-6 by the lymph node cells in vivo. In vitro incubation of the lymph node cells of DNFB-sensitized mice with PPP led to induction of these cells’ apoptosis. It seemed that modulation of the lymphocyte cytokine profile under lay the mechanism of PPP immunosuppressive activity, this leading to reduction of these cells’ proliferative activity and apoptosis induction.
psoralene / contact sensitivity / immunosuppression / apoptosis / cytokines
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