Panniculitis caused by a 4-antitrypsin deficiency

O. Yu Olisova; O. V Grabovskaya; N. P Teplyuk; T. A Belousova; I. S Dzhavakhishvili; V. A Varshavsky

doi:10.17816/dv36877

Russian Journal of Skin and Venereal Diseases ›› 2014, Vol. 17 ›› Issue (3) : 32 -35. DOI: 10.17816/dv36877

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Panniculitis caused by a 4-antitrypsin deficiency

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Abstract

Presents data on panniculitis and its different forms with special emphasis on panniculitis caused by а 1-antitrypsin (а 1-AT) deficiency, difficulties in the diagnosis and treatment of this condition. The diagnosis ofа -AT deficiency is based on clinical laboratory studies (common analysis of blood, biochemical study, ultrasonic study, esophagogastroduodenoscopy, etc.), measurement of blood а -AT concentration, and molecular genetic studies - detection of PiZZ genotype (Glu342Lys mutation in homozygotic state). The results of authors ’ observations are presented: effective systemic glucocorticosteroid therapy of panniculitis caused by а -AT deficiency.

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panniculitis / molecular genetic study / systemic glucocorticosteroids

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O. Yu Olisova, O. V Grabovskaya, N. P Teplyuk, T. A Belousova, I. S Dzhavakhishvili, V. A Varshavsky. Panniculitis caused by a 4-antitrypsin deficiency. Russian Journal of Skin and Venereal Diseases, 2014, 17(3): 32-35 DOI:10.17816/dv36877

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