Biochemical aspects of steroid resistance of autoimmune pemphigus
A. S Dukhanin , N. P Teplyuk , A. A Lepekhova , O. V Zemskova
Russian Journal of Skin and Venereal Diseases ›› 2014, Vol. 17 ›› Issue (3) : 25 -31.
Biochemical aspects of steroid resistance of autoimmune pemphigus
The molecular mechanisms of steroid resistance in patients with autoimmune pemphigus (AP) were detected at the receptor level. Comparative analysis of the parameters of glucocorticoid specific binding by peripheral blood lymphocyte receptors and of the levels of glucocorticoid a- and в-receptors in the peripheral blood lymphocytes was carried out in patients with hormone-sensitive and hormone-resistant AP. Specific features of the clinical course of AP under conditions of changed levels of a - or в-receptors in steroid-resistant patients were detected.
autoimmune pemphigus / steroid resistance / clinical course
Eco-Vector
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