Dermatoheliosis: cutaneous epithelial tumor predictor
Elena S. Snarskaya , S. B Tkachenko , E. V Kuznetsova
Russian Journal of Skin and Venereal Diseases ›› 2014, Vol. 17 ›› Issue (4) : 12 -17.
Dermatoheliosis: cutaneous epithelial tumor predictor
The incidence of ultraviolet-induced cutaneous tumors is steadily increasing all over the world (in the USA, Europe, Russia). According to the WHO data, about 140 000 melanoma cases and more than 2 000 000 cases with other variants of malignant cutaneous tumors are diagnosed annually, every third case is basal-cell cutaneous cancer. The main carcinogen responsible for the development of cutaneous tumors and provoking early development of photoaging UV spectrum of solar radiation. Penetrating through the epidermis, the A and B spectra rays cause direct and oxidative-stress-mediated damage to cellular DNA. Emergence of cell mutations, stimulation of carcinogenesis initiation and promotion lead to a complex of changes at the epidermal/dermal level, united by the notion “dermatoheliosis” (photoaging). The basic characteristic of dermatoheliosis, in addition to various clinical manifestations, is high risk of pre- and malignant epithelial cutaneous tumors. The most important mechanisms protecting the skin structures from UV exposure are hyperkeratosis and melanogenesis.
ultraviolet radiation / dermatoheliosis / photoaging / hyperkeratosis / melanogenesis / skin tumors
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