BACTERIAL VAGINOSIS IN PATIENTS WITH DISORDERED LOCAL IMMUNOLOGICAL REACTIVITY

Abstract

The study was carried out in 87 women of reproductive age, suffering from relapsing bacterial vaginosis. The results indicate that cicatricial deformation of the cervix uteri was one of the factors promoting the formation of pronounced changes in the local immunological tolerance, resulting in relapses of bacterial vaginosis. Reconstructive plasty by stratification after standard conservative therapy is a pathogenetically based strategy of combined treatment for bacterial vaginosis with cicatricial deformation of the cervix uteri.

Keywords

bacterial vaginosis / cicatricial deformation of cervix uteri / endocervicitis / immunoglobulins / inflammatory cytokines

References

[1] Morris M., Nicoll A., Simms I., Wilson J., Catchpole M. Bacterial vaginosis: a public health review. Br. J. Obstet. Gynaecol. 2001; 108(5): 439—50.

[2] Wilson J. Managing recurrent bacterial vaginosis. Sex. Trans. Infect. 2004; 80(1): 8—11.

[3] Klatt T.E., Cole D.C., Eastwood D.C., Barnabei V.M. Factors associated with recurrent bacterial vaginosis. J. Reprod. Med. 2010; 55(1—2): 55—61.

[4] Cauci S. Vaginal immunity in bacterial vaginosis. Curr. Infect. Dis. Rep. 2004; 6(6): 450—6.

[5] Causi S., Driussi S., Monte R., Lanzafame P., Pitzus E., Quadrifoglio F. Immunoglobulin A response against Gardnerella vaginalis hemolysin and salidase activity in bacterial vaginosis. Am. J. Obstet. Gynecol. 1998; 178(3): 511—5.

[6] Amsel R., Totten P.A., Spiegel C.A., Chen K.C., Eschenbach D., Holmes K.K. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am. J. Med. 1983; 74(1): 14—22.

[7] Alfonsi G.A., Shlay J.C., Parker S., Neher J.O. Clinical inquiries. What is the best approach for managing recurrent bacterial vaginosis? J. Fam. Pract. 2004; 53(8): 650—2.

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