Chronic urticaria associated with primary biliary cirrhosis
P. V Kolkhir , I. S Dzhavakhishvili , N. G Kochergin , T. P Nekrasova , T. P Rozina
Russian Journal of Skin and Venereal Diseases ›› 2014, Vol. 17 ›› Issue (3) : 22 -25.
Chronic urticaria associated with primary biliary cirrhosis
Chronic urticaria (CU) is one of the 20 most prevalent cutaneous diseases. It is associated with spontaneous weals, itching, and/or angioedemas persisting 6 weeks or longer. The cause of CU remains obscure in 7090% cases, in the rest cases the disease can be due to concomitant diseases, including autoimmune ones. We offer one of the first descriptions of CU associated with a rare autoimmune disease - primary biliary cirrhosis (PBC) in a female patient aged 30 years. In recent time three cases with CU associated with PBC (including cases with normal level of hepatic enzymes) have been descibed, which may indicate a relationship between these two diseases. In our observation PBC was asymptomatic for a long time, but with concomitant urticaria and high levels of hepatic enzymes and specific autoantibodies. Our data indicate the need in more profound immunological diagnosis in some cases, even with slight CU, good quality of life, response to treatment, and without other symptoms of PBC..
chronic urticaria / primary biliary cirrhosis / clinical case
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