Amylolytic nodular melanoma of the shin skin

Abstract

According to published data, the incidence of cutaneous melanoma is the highest after 50 years of age; the mortality is almost 80%, because of high metastatic potential of the tumor and low level of diagnosis of amylolytic forms of the disease. Melanoma is a familial disease in 5-12% cases; some data indicate an autosomal dominant inheriting with incomplete penetration or more intricate mechanisms of melanoma inheriting. Mutations in CD-KN2A and CDK genes are responsible for 20-25% high risk cases in families. According to modern concepts, the mechanisms of accumulated genetic mutations modulate significantly the signal route cascades and stimulate the production of adhesion molecules E- and N-cadherins, a- and b-integrin, and b-catenin, which are assumed to be the main molecular processes in the pathogenesis of melanoma. A rare clinical case is presented: afemale patient with positive oncological family history developed amylolytic nodular melanoma on the skin of the shin.

Keywords

amylolytic nodular cutaneous melanoma / pyogenic granuloma / family history / differential diagnosis / therapy

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