SKIN INVOLVEMENT IN CHRONIC LYMPHOID LEUKEMIA
Elena Aleksandrovna Muravyova , Olga Yurevna Olisova , Evgeniy Aleksandrovich Nikitin
Russian Journal of Skin and Venereal Diseases ›› 2013, Vol. 16 ›› Issue (6) : 4 -9.
SKIN INVOLVEMENT IN CHRONIC LYMPHOID LEUKEMIA
About 25% patients with CLL develop skin lesions. These lesions can be classified as specific (including skin infiltration by leukemic cells and the cutaneous form of Richter’s syndrome), secondary cutaneous tumors, and concomitant cutaneous diseases. Leukemic infiltration of the skin in CLL patients is called specific in volvement of the skin (SIS) or skin leukemia. Many authors attribute the unfavorable prognosis to the CLL transformation with specific infiltration of the skin into Richter’s syndrome and to emergence of SIS before the diagnosis of CLL. The risk of cancers in CLL patients is 3-fold higher, of skin cancer 8-fold higher than in normal subjects. The most frequent secondary tumors of the skin in CLL are basal-cell carcinoma, squamous-cell carcinoma, melanoma, Merkel’s tumor. Nonspecific cutaneous changes vary greatly and are detected in 30—50% CLL patients. The most prevalent secondary changes in the skin in CLL are those of infectious nature. These patients can also develop hypersensitivity reactions to insect bites, generalized itching, exfoliative erythroderma, nodular erythema, paraneoplastic pemphigus, bullous pemphigoid, toxi coderma, etc.
chronic lymphoid leukemia / specific involvement of the skin / Richter’s syndrome / secondary cu taneous tumors / nonspecific involvement
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