GENE METHYLATION IN CD3+ CELLS IN PSORIASIS

V. V Sobolev; E. V Denisova; A. G Soboleva; I. M Korsunskaya; E. V Chekalin; A. D Zolotarenko; S. A Bruskin

doi:10.17816/dv36791

Russian Journal of Skin and Venereal Diseases ›› 2013, Vol. 16 ›› Issue (1) : 40 -43. DOI: 10.17816/dv36791

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GENE METHYLATION IN CD3+ CELLS IN PSORIASIS

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Abstract

Gene methylation level in CD3+ cells of psoriasis patients in comparison with that in normal subjects was analyzed using Illumina microchips. Differentially methylated locuses were detected in CD3+ cells of psoriasis patients and normal subjects. FRK, JAK1, AKAP7, DYRK1A, PRKCA, RPS6KA2 kinase genes were detected in the most methylated locuses in CD3+ cells of psoriasis patients. The clear-cut separation of the samples into two groups suggested that the level of the studied genes methylation in CD3+ cells can serve for predicting liability to psoriasis and presumably for diagnosis of its early stages.

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FRK / JAK1 / AKAP7 / DYRK1A / PRKCA / RPS6KA2 / psoriasis / methylation / FRK / JAK1 / AKAP7 / DYRK1A / PRKCA / RPS6KA2

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V. V Sobolev, E. V Denisova, A. G Soboleva, I. M Korsunskaya, E. V Chekalin, A. D Zolotarenko, S. A Bruskin. GENE METHYLATION IN CD3+ CELLS IN PSORIASIS. Russian Journal of Skin and Venereal Diseases, 2013, 16(1): 40-43 DOI:10.17816/dv36791

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