Toll receptor 4 and 9 gene polymorphisms in patients with psoriasis

V. A Okhlopkov; A. I Novikov; A. V Kononov; E. G Pomorgailo; E. A Petrova; O. V Pravdina

doi:10.17816/dv36769

Russian Journal of Skin and Venereal Diseases ›› 2013, Vol. 16 ›› Issue (3) : 26 -29. DOI: 10.17816/dv36769

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Toll receptor 4 and 9 gene polymorphisms in patients with psoriasis

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Abstract

The prevalence of TLR4 (C6898A) and TLR9 (A2848G) gene polymorphisms and their associations with case history and clinical picture were studied in 425 patients of both genders, aged 18-80 years, with advanced stage of psoriasis vulgaris. Associations of TLR4 6898C/A mutant allele A with the guttat-type psoriasis, presence of psoriasis in the patient’s close relatives, presence of concomitant infectious or parasitic diseases, low dermatological quality of life index, and frequent relapses of the pathological process were detected. The TLR9 (A2848G) mutant allele G was associated with liability to exudation of psoriatic elements, inefficiency of therapy, high PASI score before therapy and its lesser changes over the course of treatment.

Keywords

TLR9) / gene polymorphism / TLR4 / TLR9 / psoriasis / polymorphic allele incidence

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V. A Okhlopkov, A. I Novikov, A. V Kononov, E. G Pomorgailo, E. A Petrova, O. V Pravdina. Toll receptor 4 and 9 gene polymorphisms in patients with psoriasis. Russian Journal of Skin and Venereal Diseases, 2013, 16(3): 26-29 DOI:10.17816/dv36769

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[1]	Скрипкин Ю.К., Кубанова А.А., Акимов В.Г. Кожные и венерические болезни. М.:ГЭОТАР-Медиа; 2009.

[2]	Хобейш М.М. Псориаз и качество жизни. Медицинский вестник. 2006; 38: 12-3.

[3]	Sabat R., Philipp S., Hoflich C., Kreutzer S., Wallace E., Asadullah K., et al. Immunopathogenesis of psoriasis. Exp. Dermatol. 2007; 16(10): 779-98.

[4]	Молочков В.А., Бадокин В.В., Альбанова В.И., Волнухин В.А. Псориаз и псориатический артрит. М.: КМК, Авторская академия; 2007.

[5]	Федоров С.М. Псориаз: клинические и терапевтические аспекты. Русский медицинский журнал. 2001; 11: 447-51.

[6]	Nickoloff B.J., Qin J.Z., Nestle F.O. Immunopathogenesis of psoriasis. Clin. Rev. Allergy Immunol. 2007; 33(1-2): 45-56.

[7]

Galimova E., Akhmetova V., Latipov B., Kingo K., Ratsep R., Traks T., et al. Analysis of genetic variants of class II cytokine and their receptor genes in psoriasis patients of two ethnic groups from the Volga-Ural region of Russia. J. Dermatol. Sci. 2012; 68(1): 9-18. http://www.sciencedirect.com/science/article/pii/ S0923181112002320

[8]	Connolly D.J., O’Neill L.A. New developments in Toll-like receptor targeted therapeutics. Curr. Opin. Pharmacol. 2012; 12(4): 510-51. http://www.sciencedirect.com/science/article/ pii/S1471489212001002

[9]	Bowcock A.M. The genetics of psoriasis and autoimmunity. Annu. Rev. Genomics Hum. Genet. 2005; 6: 93-122.

[10]	Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета программ Statistica. М.: Медиа Сфера; 2006.