HIGH LEVELS OF STEROID-METABOLIZING ENZYMES IN THE EPIDERMIS OF PATIENTS WITH MELANOCYTIC TUMORS OF THE SKIN
A. S Malyshev , T. G Ruksha , V. I Prokhorenkov
Russian Journal of Skin and Venereal Diseases ›› 2012, Vol. 15 ›› Issue (5) : 13 -15.
HIGH LEVELS OF STEROID-METABOLIZING ENZYMES IN THE EPIDERMIS OF PATIENTS WITH MELANOCYTIC TUMORS OF THE SKIN
The functioning of the skin as a neuroimmunoendocrine system organ during development of skin tumors received insufficient attention. Many locally produced regulators, for example steroid hormones, modify the intensity of skin cell proliferation. This fact suggests their involvement in the development of pathological processes in the skin. Changes in the epidermal keratinocyte production of steroid hormones in melanocytic tumors of the skin have been evaluated. These changes can be caused by development of these abnormalities. In addition, they suggest the formation of new therapeutic approaches in these diseases.
nevuses / melanoma / steroidogenesis / cytochrome P450scc / 21-hydroxylase / 3b-hydroxysteroid dehydrogenase
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