CHANGES IN THE ACTIVITIES OF ANTIOXIDANT ENZYMES UNDER THE EFFECT OF MATRIX METALLOPROTEINASE 9 INHIBITOR IN SKIN MELANOMA BIOMODEL
R. N Belonogov , M. B Aksenenko , T. G Ruksha
Russian Journal of Skin and Venereal Diseases ›› 2012, Vol. 15 ›› Issue (3) : 55 -57.
CHANGES IN THE ACTIVITIES OF ANTIOXIDANT ENZYMES UNDER THE EFFECT OF MATRIX METALLOPROTEINASE 9 INHIBITOR IN SKIN MELANOMA BIOMODEL
Studies on skin melanoma biomodel showed that matrix metalloproteinase-9 inhibitor caused a much greater increase of superoxide dismutase activity than of catalase activity. This led to excessive formation of hydrogen peroxide, suppressing proliferation when in high concentrations. These events were paralleled by reduction of the number of tumor cells expressing the proliferating cell nuclear antigen.
melanoma / oxidative stress / matrix metalloproteinase-9 inhibitor
| [1] |
Королюк М.А., Иванова Л.И., Майорова И.Г. //Лабораторное дело. — 1988. — № 1. — С. 16—17. |
| [2] |
Окислительный стресс: Патологические состояния и заболевания. Меньщикова Е.Б., Зенков Н.К., Ланкин В.3. и др. — Новосибирск: АРТА; 2008. |
| [3] |
Сирота Т.В. // Вопр. мед. химии. — 1999. — Т. 45, вып. 3. — С. 263—272. |
| [4] |
Шайн А.А. Онкология. — Тюмень: Академия; 2004. — Т. 4. |
| [5] |
Yoon S.-O., Park S.-J., Yun C.-H., Chung A.-S. // J. Biochem. Mol. Biol. — 2003. — Vol. 36, N 1. — P. 128—137. |
| [6] |
Zaidi R., Day C.-P., Merlino G. // J. Invest. Dermatol. — 2008. — Vol. 128. — P. 2381-2391. |
Eco-Vector
/
| 〈 |
|
〉 |
PDF
