THE ROLE OF ANTICHOLINERGIC PROPERTIES OF DRUGS IN THE DEVELOPMENT OF FALLS IN PATIENTS OF SENILE AGE
Ekaterina S. Ilina , S. P Bordovsky , N. I Polshina , V. E Nikulin , S. V Gorbotenkova , O. T Bogova , T. A Ivanova , I. V Lyalina , D. A Sychev
Medical and Social Expert Evaluation and Rehabilitation ›› 2018, Vol. 21 ›› Issue (1-2) : 89 -93.
THE ROLE OF ANTICHOLINERGIC PROPERTIES OF DRUGS IN THE DEVELOPMENT OF FALLS IN PATIENTS OF SENILE AGE
The article presents own results of the effect of anticholinergic properties of drugs on the development of falls in senile cardiovascular disease (CVD) patients under conditions of polypharmacy. The total anticholinergic load was calculated according to the ACBS scale (Anticholinergic Cognitive Burden Scale). Our study showed the ACB scale to be convenient and allows us to identify designations of dangerous drugs that can disrupt cognitive abilities in CVD patients of older age groups, leading to a fall.
patients of senile age / cardiovascular diseases / anticholinergic activity / total anticholinergic load / drugs / falls / Anticholinergic Cognitive Burden (ACB) scale
| [1] |
Падения. Информационный бюллетень ВОЗ. Август 2017 г. http://www.who.int/mediacentre/factsheets/fs344/ru/ |
| [2] |
Baranzini F., Diurni M., Ceccon F., Poloni N., Cazzamalli S., Costantini C. et al. Fall-related injuries in a nursing home setting: Is polypharmacy a risk factor? BMC Health Services Res. 2009;9: 228. |
| [3] |
National Institute for Health and Care Excellence (NICE). Falls in older people. http://pathways.nice.org.uk/pathways/falls-in-older-people |
| [4] |
WHO Global Report on Falls Prevention in Older Age. Community Health.2007. http://www.who.int/ageing/publications/Falls_prevention7March.pdf. |
| [5] |
Coutinho Ed Eda S., Silva S.D. Medication as a risk factor for falls resulting in severe fractures in the elderly. Cad. Saude Publica. 2002; 18: 1359-66. |
| [6] |
Cumming R.G., Klineberg R.J. Psychotropics, thiazide diuretics and hip fractures in the elderly. Med. J. 1993; 158: 414-17. |
| [7] |
Monane M., Avorn J. Medications and falls: causation, correlation, and prevention. Clin. Geriatr. Med. 1996; 12: 847-58. |
| [8] |
Leipzig R.M., Cumming R.G., Tinetti M.E. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J. Am. Geriatr. Soc.1999; 47: 30-9. |
| [9] |
Leipzig R.M., Cumming R.G., Tinetti M.E. Drugs and Falls in Older People: a Systematic Review and Meta-Analysis: II. Cardiac and Analgesic Drugs. JAGS. 1999; 47: 40-50. |
| [10] |
Tinetti M.E., Han L., Lee D.S.H. et al. Antihyprttensive medications and serious injuriesin a national representative sample of older adults. JAMA Intern. Med. 2014; 174 (4): 588-95. |
| [11] |
Woolcott J.C., Richardson K.J., Wiens M.O. et all. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch. Intern. Med. 2009, 169: 1952-60. 10.1001/archinternmed.2009.357. |
| [12] |
Carnahan R.M., Lund B.C., Perry P.J., Pollock B.G., Culp K.R. The Anticholinergic Drug Scale as measure of drug related anticholinergic burden: association with serum anticholinergic activity. J. Clin. Pharmacol. 2006; 46: 1481-6. |
| [13] |
Salahudeen M.S., Duffull S.B., Nishtala P.S. Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review. BMC Geriatr. 2015; 15: 31. |
| [14] |
Carrière I., Fourrier-Reglat A., Dartigues J.-F. Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study. Arch. Intern. Med. 2009; 169 (14): 1317-24. doi: 10.1001/archinternmed.2009.229 |
| [15] |
http://www.agingbraincare.org/tools/abc-anticholinergic-cognitive-burden-scale |
| [16] |
Fox C., Richardson K., Maidment I. et al. Anticholinergic medication use and cognitive impairment in the older population: the Medical Research Council Function and Ageing Study. J. Am. Geriatr. Soc. 2011; 59(8): 1477-83. |
| [17] |
Richardson K., Bennett K., Maidment I.D. et al. Use of Medications with Anticholinergic Activity and Self-Reported Injurious Falls in Older Community-Dwelling Adults. J. Am. Geriatr. Soc. 2015; 63(8): 1561-9. |
| [18] |
Назаренко Г.И., Клейменова Е.Б., Отделенов В.А. и др. Использование триггеров нежелательных событий для выявления побочных реакций при применении лекарственных средств в стационаре. Клиническая фармакология и терапия. 2015. 24 (4): 55-62. |
Eco-Vector
/
| 〈 |
|
〉 |