Effect of weight loss on erectile function and quality of life in obese men

Abstract

In recent years there has been a sharp increase in the prevalence of obesity in the world that stimulate interest in the effects on health and quality of life of the phenomenon. In developed countries, obesity is considered the fifth most significant riskfactorfor disability. Quality of life of obese patients is an important issue that must be considered more carefully. Unfortunately, not enough studied the effect weight loss on sexual function and quality of life. Consequently, the aim of our study was to - to study the effect of weight loss on erectile function and quality of life in men with obesity. The study involved 40 men aged 30 to 50 years, mean age 43,4 ± 7,5, BMI 40,4 ± 7. At the initial ethane we measured anthropometric indicators, questionnaires using the International Index of Erectile Function-5, Hospital Anxiety and Depression Scale, the Russian version of the general questionnaire MOS-SF-36 (MOSSF-Item Short Form Health Survey). Further, all patients received sibutramine 10-15 mg (Reduxine, Promo-Med) on a par with changing lifestyles within 6 months. We have found that with the increase in severity of erectile function were growing anxiety symptoms (r = 0,521; p < 0,05) and depression (r = 0,593; p < 0,01). After weight loss the patients’ quality of life significantly improved in terms ofpsychological health, as well as indicators ofviability and role emotional functioning. Conclusions: Obesity reduces the quality of life ofpatients, leading to the development of erectile dysfunction, depression and anxiety, moderate weight loss is largely due to the improved quality of life, erectile function, decrease symptoms of anxiety/depression.

Keywords

obesity / erectile dysfunction / quality of life / sibutramine

References

[1] Flegal K.M., Carroll M.D., Ogden C.L., Johnson C.L. Prevalence and trend in obesity among US adults, 1999-2000. J. A. M. A. 2002; 288: 1723-7.

[2] WHO. Diet, Nutrition and the Prevention of Chronic Diseases. Report of a Joint WHO/FAO Expert Consultation. World Health Organization; 2003.

[3] Kolotkin R.L., Meter K., Williams G.R. Quality of life and obesity. Obesity Rev. 2001; 2 (4): 219-29.

[4] Seidell J.C. The impact of obesity on health status: some implications for health care costs. Int. J. Obes. Relat. Metab. Disord. 1995; 19: S13-6.

[5] Fontaine K.R., Cheskin L.J., Barofsky I. Health-related quality of life in obese persons seeking treatment. J. Fam. Pract. 1996; 43: 265-70.

[6] Fine J.T., Colditz G.A., Coakley E.H., Moseley G., Manson J.E., Willett W.C. et al. A prospective study of weight change and health-related quality of life in women. J. A. M. A. 1999; 282: 2136-42.

[7] Larsson U., Karlsson J., Sullivan M. Impact of overweight and obesity on health-related quality of life - a Swedish population study. Int. J. Obes. Relat. Metab. Disord. 2002; 26: 417-24.

[8] Wespes E., Amar E., Hatzichristou D., Montorsi F., Pryor J., Vardi Y. Guidelines on erectile dysfunction. Eur. Urol. 2002; 41: 1-5.

[9] Wolf A.M. Introduction: Task Force on Developing Obesity Outcomes and Learning Standards (TOOLS). Obes. Res. 2002; 10 (Suppl. 1): 1S-2S.

[10] Shape Up America, American Obesity Association. Guidance for Treatment of Adult Obesity (Bethesda 1996). Available at: http://www.shapeup.org.

[11] Kinzl J.F., Trefalt E., Fiala M., Hotter A., Biebl W., Aigner F. Partnership, sexuality, and sexual disorders in morbidly obese women: consequences of weight loss after gastric banding. Obes. Surg. 2001; 11: 455-8.

[12] Larsen F. Psychosocial function before and after gastric banding surgery for morbid obesity. A prospective psychiatric study. Acta Psychiat. Scand. Suppl. 1990; 359: 1-57.

[13] Rand C.S., Kowalske K., Kuldau J.M. Characteristics of marital improvement following obesity surgery. Psychosomatics. 1984; 25: 221-3, 6.

[14] Camps M.A., Zervos E., Goode S., Rosemurgy A.S. Impact of Bariatric surgery on body image perception and sexuality in morbidly obese patients and their partners. Obes. Surg. 1996; 6: 356-60.

[15] Esposito K., Giugliano F., Di Palo C., Giugliano G., Marfella R., D’Andrea F. et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. J. A. M. A. 2004; 291: 2978-84.

[16] Kim K.K., Kang H.C., Kim S.S., Youn B.B. Influence of weight reduction by sibutramine on female sexual function. Int. J. Obes. 2006; 30: 758-63.

[17] Althof S.E., Cappelleri J.C., Shpilsky A., Stecher V., Diuguid C., Sweeney M. et al. Treatment responsiveness of the self-esteem and relationship questionnaire in erectile dysfunction. Urology. 2003; 61: 888-92.

[18] Бутрова С.А., Берковская М.А., Комшилова К.А. Опыт применения препарата Редуксин (Сибутрамин) у больных с метаболическим синдромом. Ожирение и метаболизм. 2007; 4: 34-9.

[19] Bray G.A., Blackburn G.L., Ferguson J.M., Greenway F.L., Jain A.K., Mendel C.M. et al. Sibutramine produces dose-related weight loss. Obes. Res. 1999; 7: 189-98.

[20] Smith I.G., Goulder M.A. Randomized placebo-controlled trial of long-term treatment with sibutramine in mild to moderate obesity. J. Fam. Pract. 2001; 50: 505-12.

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