Clinical and laboratory characteristics of influenza in pregnant women in the epidemiological season of 2013-2014

Abstract

By force of hormonal and physiological changes occurring in the body throughout pregnancy, in the case of the flu, pregnant women are at greater risk of developing complications. In this regard, the study of clinical and pathogenetic features of influenza in pregnant women deserves special attention. So, on the basis of epidemiological data over the past few decades, WHO experts have included pregnant women in groups at risk of severe (complicated) course of the flu. The flu for a pregnant female is a dangerous infection, representing a real threat to the health of the expectant mother and her child. The clinical picture of influenza in pregnant women can vary significantly, and severe complications combine with the development of a pathology of pregnancy, which ultimately exacerbates the condition as well an expectant mother as the fetus. For the study both of the character of the clinical course of influenza in pregnant women and the mechanism of the immunosuppressive state FGBU "Influenza Research Institute" performed a simple multi-center comparative study on the base of the infectious-disease units of the GBOU "NGMU" and the Medical University "KrasGMU named after. prof. V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation. The obtained results allowed to reveal some clinical and immunological features of the course of influenza in pregnant women: at the peak of the disease there was noted a significant inhibition of induced production of IFN-γ.

Keywords

influenza / acute respiratory viral infection / pregnancy / influenza in pregnant women

References

[1] Van Kerkhove M.D., Vandemaele K.A., Shinde V., Jaramillo-Gutierrez G., Koukounari A. et al. Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med. 2011; 8(7):e1001053. doi: 10.1371/journal.pmed.1001053. Epub 2011 Jul 5.

[2] Lim Boon H., Mahmood Tahir A. Influenza A H1N1 2009 (Swine Flu) and Pregnancy. United Kingdom Obstetric Surveillance System (UKOSS). 2010.

[3] Киселев О.И., Покровский В.И. Грипп при беременности: сочетание функциональной и инфекционной иммуносупрессии. СПб.: Принт; 2012.

[4] Jain S., Kamimoto L., Bramley A.M., Schmitz A.M., Benoit S.R., Louie J. et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N. Engl. J. Med. 2009; 361(20): 1935-44.

[5] Webb S.A., Pettilä V., Seppelt I., Bellomo R., Bailey M., Cooper D.J. et al. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N. Engl. J. Med. 2009; 361: 1925-34.

[6] Shears P., Sluman C., Harvey D. Sever Bacterial Sepsis Associated with Influenza: Antimicrobial Management in Adults. Clinical guideline. 2012; vol. 2.

[7] Kanellopoulos-Langevin С., Caucheteux S.M., Verbeke P., Ojcius D.M. Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface. Reprod. Biol. Endocrinol. 2003; 1: 121.

[8] Uchide N., Ohyama K., Bessho T., Takeichi M., Toyoda H. Possible roles of proinflammatory and chemoattractive cytokines produced by human fetal membrane cells in the pathology of adverse pregnancy outcomes associated with influenza virus infection. Mediat. Inflamm. 2002; Vol. 2012 (2012), Article ID 270670, 32 pages http://dx.doi.org/10.1155/2012/270670

[9] Çetinkaya M., Özkan H., Çelebi S., Köksal N., Hacımustafaoğlu M. Human 2009 influenza A (H1N1) virus infection in a premature infant born to an H1N1-infected mother: placental transmission? Turk. J. Pediatr. 2011; 53: 441-4.

[10] Киселев О.И. Определение интерферонового статуса как метод оценки иммунореактивности при различных формах патологии: Пособие для врачей. СПб.: Принт; 2002.

[11] Сенников С.В., Силков А.Н. Методы определения цитокинов. Цитокины и воспаление. 2005; 4(1): 22-7.

[12] WHO. WHO Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza. 2011.

[13] Соминина А.А., Бурцева Е.И., Лобова Т.Г. и др. Выделение вирусов гриппа в клеточных культурах и куриных эмбрионах и их идентификация: Методические рекомендации. СПб.: Медицинское информационное агентство. 2006.

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