Diversity of LPS/O-antigens of causative agents of intestinal infections in HIV-infected patients at the stage of secondary diseases
E. G Korogodskaia , K. T Umbetova , O. F Belaia , A. I Mazus , Yu. V Yudina , Yu. A Belaia , S. V Smetanina , M. N Allenov , S. G Pak
Epidemiology and Infectious Diseases ›› 2015, Vol. 20 ›› Issue (1) : 4 -7.
Diversity of LPS/O-antigens of causative agents of intestinal infections in HIV-infected patients at the stage of secondary diseases
The goal was to establish the frequency of detection of LPS O antigens of common causative agents of intestinal infections in HIV-infected patients at the stage of secondary diseases. Materials and methods. The study included 48 HIV-infected patients at the stage 4A, 4Б, 4B (25 men and 23 women), without diarrhea, a mean age ofpatients was 36,78 ± 7,8 years. Stool samples (2-4 samples from patient in interval of 5-7 days) were studied for the presence of LPS/O-antigens of S.sonnei, S.flexneri 1-5, 6, Salmonella sgr. B, C1, C2, D, E, Y.pseudotuberculosis I, III, Y.enterocolitica 03, 09, Campylobacter (C.jejuni, C.coli, C.lari) in coagglutination. Results. It was found that HIV-infected patients at the stage of secondary diseases have relatively high presence of LPS/Oantigens of various pathogens - Shigella, Salmonella, Yersinia, in feces (72, 55%). But Campylobacter antigens were relatively rare. In stages 4A, 4Б and 4В overall detection rate of LPS/O-antigens in stool samples did not differ significantly and was 64,3%, 91,3%, 68,6%, respectively (r ≥ 0,05). Conclusion. The high content of LPS/O-antigens may increase the toxic load in patients with HIV infection, including the immune system.
HIV infection / lipopolysaccharide / O-antigens / intestinal bacteria / coagglutination
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