FEATURES OF THE CYTOKINE PROFILE IN CHILDREN SUFFERING FROM PERTUSSIS

O. P Popova; I. M Fedorova; S. I Koteleva

doi:10.17816/EID40779

Epidemiology and Infectious Diseases ›› 2013, Vol. 18 ›› Issue (5) : 33 -37. DOI: 10.17816/EID40779

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FEATURES OF THE CYTOKINE PROFILE IN CHILDREN SUFFERING FROM PERTUSSIS

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Abstract

Comparative analysis of cytokine profile was performed in 149 children aged 1.5 to 14 years, out of which 41 had suffered from pertussis as monoinfection, 53 -in combination with mycoplasma infection, 55 - with acute viral infections. Cytokine profile in patients with pertussis differs in reduction of induced production of proinflammatory cytokines, especially IFN-y. A key feature of the functioning of the cytokine network in pertussis is the active production of anti-inflammatory cytokines - IL-4 and IL-10 upward the early periods of the disease, that indicates the importance of Th-2-type response in whooping cough.

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pertussis / cytokine production / proinflammatory / antiinflammatory / interferons / interleukins

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O. P Popova, I. M Fedorova, S. I Koteleva. FEATURES OF THE CYTOKINE PROFILE IN CHILDREN SUFFERING FROM PERTUSSIS. Epidemiology and Infectious Diseases, 2013, 18(5): 33-37 DOI:10.17816/EID40779

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