PROSPECTS OF THE USE "STIMFORTE" IN CHRONIC HEPATITIS B
L. V Pogorelskaya , I. N Khlopova , S. S Grigoryan , I. P Tryakina , N. A Rick , D. G Maldov
Epidemiology and Infectious Diseases ›› 2013, Vol. 18 ›› Issue (5) : 15 -20.
PROSPECTS OF THE USE "STIMFORTE" IN CHRONIC HEPATITIS B
Despite the fact that over the last few years downward trend in the incidence of acute forms of viral hepatitis B continues, the incidence of chronic hepatitis B (CHV) has increased by 2.5 times since 1998. To date, there are a sufficient number of antiviral drugs, but their use is associated with a set of contraindications, as well as the development of resistance. In this study there was performed an evaluation of a new national drug " Stimforte " in patients with chronic viral hepatitis B (CVHB - DNA positive, HBsAg - positive) at the stage of exacerbation. In the study there were included 28 patients with chronic hepatitis B (HBsAg positive), at different grades of activity, at a stage of viral replication. The diagnosis of chronic hepatitis B was made on the presence in a history acute viral hepatitis for more than 1 year, complaints, hepatolienal, astenovegetative, cytolytic syndromes, the presence of DNA-HBV, anti-HBcore IgM, HBsAg. After 1 course of treatment with " Stimforte " the well-being of patients has improved: in 30% of patients asthenic- vegetative syndrome had disappeared, weakness, fatigue and dyspeptic symptoms were decreased. The use of "Stimforte" in chronic hepatitis B with positive HBsAg at the stage of exacerbation contributed to a more rapid normalization of such indices as ALT, AST, compared with those in the control group. Long-term biochemical and virological remission was achieved in 40 %. It is established that during the treatment the viral load was reduced progressively until the undetectable or low level of HBV DNA and anti-HBc IgM disappeared. In only one case an allergic reaction was observed, which has not hindered to perform a complete course of treatment. No other side effects were detected. The inclusion of the drug "Stimforte" in the complex therapy of patients with exacerbation of chronic hepatitis B reduces the time of recovery of immune status and functional activity of IFN system and contributes to reduction of the viral load or elimination of the virus.
Chronic hepatitis B / treatment / "Stimforte"
| [1] |
Fan H.L., Yang P.S., Chen H.W. et al. Predictors of the outcomes of acute-on-chronic hepatitis B liver failure. World J. Gastroenterol. 2012; 18(36): 5078-83. |
| [2] |
Погорельская Л.В., Никитина Г.Ю., Алешкович Т.В., Чемерис О.Ю. Применение стимфорте при хроническом гепатите В. Актуальные вопросы организации лечебно-диагностического процесса в многопрофильной клинической больнице. В кн.: Тезисы докладов на научно-практической конференции, посвященной 100-летию Государственной клинической больницы имени С.П. Боткина. 1910-2010. М.; 2010: 218-9. |
| [3] |
Ильичев А.В., Бельков А.П., Мальдов Д.Г., Асташкин Е.И. Секреция гранул нейтрофилов человека под действием формил пептида и препарата «Стимфорте». Иммунология. 2009; 3: 159-61. |
| [4] |
Мальдов Д.Г., Бельков А.П., Ильичев А.В., Асташкин Е.И. Влияние комплексного гидрофильного низкомолекулярного препарата «Стимфорте» на функциональную активность фагоцитов крови человека. Иммунология. 2009; 2: 95-7. |
| [5] |
Хоперская О.А. (RU), Мальдов Д.Г. (RU), Асташкин Е.И. (RU). Патент № 008646. Реестр евразийских патентов. Евразийское патентное ведомство; 2007: 10. |
| [6] |
Российский статистический ежегодник. Заболеваемость населения по основным классам болезней. М.: 2012. Федеральная служба государственной статистики. |
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