CLINICAL AND LABORATORY FEATURES OF HHV-6 INFECTION IN IMMUNOCOMPROMISED CHILDREN FOLLOWED UP AT THE CHILDREN’S POLYCLINIC

I. I Lvova; A. V Deryusheva; N. S. Legotina; E. V Sidor

doi:10.17816/EID40742

Epidemiology and Infectious Diseases ›› 2013, Vol. 18 ›› Issue (4) : 35 -39. DOI: 10.17816/EID40742

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CLINICAL AND LABORATORY FEATURES OF HHV-6 INFECTION IN IMMUNOCOMPROMISED CHILDREN FOLLOWED UP AT THE CHILDREN’S POLYCLINIC

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Abstract

In a cohort of 100 immunocompromised children aged 3 months to 12 years in continuous screening of saliva and urine with a qualitative polymerase chain reaction (PCR) assay DNA herpes virus 4, 5, 6, type (CMV, EBV, HHV-6) were verified in 76% of cases. DNA herpes virus type 6 was detected significantly more often (56%). On the material of the primary medical documentation and data of clinical and laboratory examination in conditions of a children's polyclinic there was performed the analysis of clinical and epidemiological risk factors for intrauterine infection (IUI), and clinical and laboratory markers of secondary immune deficiency (SID). It was made a suggestion about predominant vertical transmission of HHV-6 during the antenatal period. Based on 100 percent of detection of opportunistic herpes viral DNA in children aged 1-3 years the tactics of "antigenic sparing" in young children with SID was justified. To optimize the diagnostic measures in respect of immunocompromised children in conditions of a children's polyclinic the performance of a comprehensive screening PCR testing for HSV infections, including HHV-6, as well as immunological and bacteriological control is proposed.

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herpes virus type 6 / children / secondary immune deficiency

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I. I Lvova, A. V Deryusheva, N. S. Legotina, E. V Sidor. CLINICAL AND LABORATORY FEATURES OF HHV-6 INFECTION IN IMMUNOCOMPROMISED CHILDREN FOLLOWED UP AT THE CHILDREN’S POLYCLINIC. Epidemiology and Infectious Diseases, 2013, 18(4): 35-39 DOI:10.17816/EID40742

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