THE STUDY OF THE ANTIMICROBIAL ACTIVITY OF SOME NEW AZO DERIVATIVES OF PYRIDOXINE AND THEIR ZINC COMPLEXES

Abstract

For the first time with the use of conventional techniques the overall toxicity and the antimicrobial activity of some new substances - pyridoxine azo derivatives (mercurions), obtained an international registration (CAS, USA) and their zinc-complexes have been studied. St. aureus, E.coli, Pseudomonas aeruginosa, and Candia albicans were used as a test cultures. The investigated compounds were established to have low toxicity (LD 50 failed to detect, with a maximum dose of introduced animals as 0.01 g ≈ 20 g), and some of them were shown to have pronounced antimicrobial activity. In contrast to free mercurions their zinc complexes show activity against strains of some microorganisms (St. aureus, Candida albicans), as well as similar antimicrobial activity in the lower (2-4 fold) concentrations.

Keywords

antimicrobial activity / general toxicity / azo derivatives of pyridoxine (mercurions) / zinc complexes

References

[1] Алиев А. М., Алиев Ф. И. // Азерб. фармац. журн. - 2005. -№ 1. - С. 17-22.

[2] Алиев А. М., Алиев Ф. И., Асадова А. И. и др. // Азерб. фармац. и фармакотер. журн. - 2007. - № 1. - С. 18-21.

[3] Алиев Н. Н., Гейдарова Ф. А., Асадова А. И. // Азерб. фармац. и фармакотер. журн. - 2008. - № 2. - С. 41-42.

[4] Алиев А. М., Мамедов Ф. И. // Азерб. фармац. и фармакотер. журн. - 2010. - № 2. - С. 5-12.

[5] Гейдарова Ф. А. // Азерб. фармац. и фармакотер. журн. - 2009. - № 1. - С. 37-38; № 2. - С. 62-64.

[6] Машковский М. Д. Лекарственные средства. - М., 2008.

[7] Методические указания по изучению общетоксического действия фармакологических веществ: Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ. - М., 2000. - С. 18-29.

[8] Методические указания по изучению противомикробной активности фармакологических веществ. - М., 2000. - С. 264-273.

RIGHTS & PERMISSIONS

Eco-vector