Efficiency of treatment with first-line drugs in patients with recurrent tuberculosis of different types of drug resistance on the basis of cohort analysis

Gul'nara Tmukhanovna Khauadamova; Tleukhan Shildebaevich Abildaev; Anar Saduevna Rakisheva; Galina Alekseevna Myasnikova; Yana Vadimovna Besstrashnova; G T Khauadamova; T Sh Abildayev; A S Rakisheva; G A Myasnikova; Ya V Besstrashnova

doi:10.17816/EID40641

Epidemiology and Infectious Diseases ›› 2011, Vol. 16 ›› Issue (6) : 33 -38. DOI: 10.17816/EID40641

Articles

other

Efficiency of treatment with first-line drugs in patients with recurrent tuberculosis of different types of drug resistance on the basis of cohort analysis

Author information +

National Center for Tuberculosis Problems of the Republic of Kazakhstan, Almaty

Show less

History +

PDF

Abstract

The purpose of the investigation was to study the efficiency of treatment with essential drugs in patients with recurrent tuberculosis of different types of drug resistance on the basis of cohort analysis.A cohort retrospective study was conducted in 94 patients with recurrent pulmonary tuberculosis. The study enrolled more than 18-year-old bacteria-excreting patients admitted to the Therapeutic Unit, National Center for Tuberculosis Problems, in 2006 to 2008. All the patients received category II chemotherapy regimen with first-line drugs.According to the type of drug resistance, the patients were divided into 3 groups: 1) mono-; 2) poly-; 3) multi-resistance.The investigation yielded the following results. In shorter periods (3 months), sputum smear conversion was achieved in patients with mono- (90.0%), poly- (64.7%), and multi- (32.8%) resistance. Overall, sputum smear conversion at 5 months was achieved in 90.0, 88.1, and 74.5% cases, respectively.Positive X-ray changes as decay cavity reduction (70.0%) and closure (30.0%) were most common in the mono-resistance group. On the contrary, X-ray progression was ascertained in poly- (11.7%) and multi- (16.4%) resistant patients.The cohort analysis showed that the best results of treatment were achieved in mono-resistant patients (90.0%). On the contrary, the worst treatment results were recorded in multi-resistant patients (24.6%). All those who died of tuberculosis (8%) had formed a multi-resistance group.

Keywords

recurrent tuberculosis / drug resistance / cohort analysis

Cite this article

Download citation ▾

Gul'nara Tmukhanovna Khauadamova, Tleukhan Shildebaevich Abildaev, Anar Saduevna Rakisheva, Galina Alekseevna Myasnikova, Yana Vadimovna Besstrashnova, G T Khauadamova, T Sh Abildayev, A S Rakisheva, G A Myasnikova, Ya V Besstrashnova. Efficiency of treatment with first-line drugs in patients with recurrent tuberculosis of different types of drug resistance on the basis of cohort analysis. Epidemiology and Infectious Diseases, 2011, 16(6): 33-38 DOI:10.17816/EID40641

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Абашев И. М., Козлова А. И., Иванова Л. А. Результаты лечения больных деструктивным туберкулезом легких без учета лекарственной чувствительности микобактерий туберкулеза // Пробл. туб. и бол. легких. - 2008. - № 1. - С. 33-35.

[2]	Агзамова Р. А. Эпиднадзор за лекарственной устойчивостью // Материалы Международного семинара "Контроль над лекарственно-устойчивым туберкулезом в Казахстане". - Алматы, 2001. - С. 5-9.

[3]	Богуш Т. А., Покатаева И. А., Тимофеева Н. В., Ожерельев А. С. Новый маркер множественной лекарственной резистентности - BCRP // Антибиотики и химиотер. - 2003. - Т. 48, № 6. - С. 33-41.

[4]	Мишин В. Ю., Григорьев Ю. Г. Лекарственно-устойчивый туберкулез легких: Учеб.-метод. пособие. - М., 2001. - С. 26.

[5]	Ракишева А. С. Лекарственная устойчивость микобактерий туберкулеза в исправительных учреждениях // Материалы Международного семинара "Контроль над лекарственно-устойчивым туберкулезом в Казахстане". - Алматы, 2001. - С. 80-84.

[6]	Сафарян М. Д., Минасян Г. Р., Хачатрян Д. Г., Стамболиян Е. П. Прогнозирование риска развития лекарственной устойчивости возбудителя легочного туберкулеза // Пробл. туб. и бол. легких. - 2008. - № 9. - С. 40-44.

[7]	Трифонова А. Ю., Стаханов В. А., Полунина Н. В. и др. Медико-социальные и психологические аспекты заболеваемости населения туберкулезом в современных условиях // Рос. мед. журн. - 2005. - № 5. - С. 9-11.

[8]

Хауадамова Г. Т., Кудрявцева Я. В., Сыздыкова Н. С. и др. Показания и противопоказания для назначения препаратов резервного ряда у больных с MDR при рецидивах и неудачах лечения // Материалы Международной конф. "Новые диагностические и образовательные технологии во фтизиатрии и пульмонологии". - Алматы, 2003. - С. 61-62.