Study of the levels of soluble forms of differentiation antigens in patients with herpes zoster
Devora Mikhaylovna Sobchak , Ol'ga Vladimirovna Korochkina , Tat'yana Aleksandrovna Svintsova , Galina Anatol'evna Kravchenko , Viktor Vladimirovich Novikov , D M Sobchak , O V Korochkina , T A Svintsova , G A Kravchenko , V V Novikov
Epidemiology and Infectious Diseases ›› 2011, Vol. 16 ›› Issue (6) : 18 -23.
Study of the levels of soluble forms of differentiation antigens in patients with herpes zoster
The high incidence of herpesvirus infections is one of the topical problems of modern medicine. Herpesviruses are widely spread in the human population; they are able to affect virtually all organs and systems of the host, by causing latentDifferentiation antigens (sCD95, sCD18, sCD50, sHLAI, sCD54) was studied by enzyme immunoassay using monoclonal antibodies (Ab) ICO-20 and polyclonal Abs to antigens of human peripheral blood mononuclear cells. A control group included 60 health donors matched with the study group for age and gender.Age over 60 years, moderate herpes zoster, eruptions on the torso, no comorbidities, and a 1.5-2-fold increase in sHLAI as compared with the reference values were found to be factors that contribute to the uncomplicated course of the disease. The cofactors of postherpetic neuralgia were elderly age (more than 60 years), the severe course of the disease, eruptions on the head, comorbidities, elevated blood urea levels, a 1.5-2-fold decrease in sCD95 and sCD54 as compared to the reference values.
herpes zoster / postherpetic neuralgia / differentiation antigens / interleukins / tumor necrosis factor
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