Molecular mechanisms of Mycobacterium tuberculosis resistance to reserve-series drugs
Anastasiya Valer'evna Nizova , Valentina Nikolaevna Stepanshina , Igor' Georgievich Shemyakin , A V Nizova , V N Stepanshina , I G Shemyakin
Epidemiology and Infectious Diseases ›› 2011, Vol. 16 ›› Issue (5) : 33 -38.
Molecular mechanisms of Mycobacterium tuberculosis resistance to reserve-series drugs
The review presents the data currently available in the literature on the mechanisms responsible for the development of resistance in Mycobacterium tuberculosis to reserve-series drugs, such as prothionamide, ethionamide, kanamycin, amikacin, capreomycin, cycloserine, rifabutin, PAS, and a group of fluoroquinolones.
M. tuberculosis / M. tuberculosis / resistance / gene / mutation / prothionamide / ethionamide / kanamycin / amikacin / capreomycin / cycloserine / rifabutin / PAS / fluoroquinolones
| [1] |
Кузьмин А. В., Васильева И. А., Черноусова Л. Н. Эффективность химиотерапии деструктивного туберкулеза легких, основанной на результатах экспресс-детекции лекарственной чувствительности к изониазиду и рифампицину тест-системой ТБ-биочип // Пробл. туб. и бол. легких. - 2006. - № 8. - С. 17-23. |
| [2] |
Мишин В. Ю., Чуканов В. И., Васильева И. А. К проблеме оптимизации и доказательности современных режимов химиотерапии туберкулеза легких // Пробл. туб. и бол. легких. - 2004. - № 8. - С. 7-11. |
| [3] |
Носова Е. Ю., Галкина К. Ю., Маркова О. В. и др. Изучение лекарственной чувствительности Mycobacterium tuberculosis к фторхинолонам путем выявления мутаций в гене gyrA // Пробл. туб. и бол. легких. - 2007. - № 10. - С. 57-60. |
| [4] |
Приказ Министерства здравоохранения РФ № 109 от 21 марта 2003 г. О совершенствовании противотуберкулезных мероприятий в Российской Федерации. - М., 2003. |
| [5] |
Туберкулез. Патогенез, защита, контроль / Под ред. Барри Р. Блума; пер. с англ. - М., 2002. |
| [6] |
Alangaden G. J., Kreiswirth B. N., Aouad A. et al. // Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis // Antimicrob. Agents Chemother. - 1998. - Vol. 42, N 5. - P. 1295-1297. |
| [7] |
Aubry A., Veziris N., Cambau E. et al. Novel gyrase mutations in quinolone-resistant and hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes // Antimicrob. Agents Chemother. - 2006. - Vol. 50, N 1. - P. 104-112. |
| [8] |
Banerjee A., Dubnau E., Quemard A. et al. InhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis // Science. - 1994. - Vol. 263, N 5144. - P. 227- 230. |
| [9] |
Baulard A. R., Betts J. C., Endohang-Ndong J. et al. Activation of the pro-drug ethionamide is regulated in mycobacteria // J. Biol. Chem. - 2000. - Vol. 275, N 36. - P. 28326-28331. |
| [10] |
Ca'ceres N. E., Harris N. B., Wellehan J. F. et al. Overexpression of the D-Alanine racemase gene confers resistance to D-Cycloserine in Mycobacterium smegmatis // J. Bacteriol. - 1997. - Vol. 179, N 16. - P. 5046-5055. |
| [11] |
Chan R. C. Y., Hui M., Chan E. W. C. et al. // Genetic and phenotypic characterization if drug-resistant Mycobacterium tuberculosis isolates in Hong Kong // J. Antimicrob. Chemother. - 2007. - Vol. 59, N 1. - P. 866-873. |
| [12] |
Chikamatsu K., Mizuno K., Yamada H., Mitarai S. Cross-resistance between rifampicin and rifabutin among multi-drug resistant Mycobacterium tuberculosis strains // Kekkaku. - 2009. - Vol. 84, N 9. - P. 631-633. |
| [13] |
David H. L. Resistance to D-Cycloserine in the tubercle bacilli: mutation rate and transport of alanine in parental cells and drug-resistant mutants // J. Bacteriol. - 1971. - Vol. 21, N 5. - P. 888-892. |
| [14] |
DeBarber A. E., Mdluli K., Bosman M. et al. Ethionamide activation and sensitivity in multidrug resistant Mycobacterium tuberculosis // Proc. Natl Acad. Sci. USA. - 2000. - Vol. 97, N 17. - P. 9677-9682. |
| [15] |
Devasia R. A., Blackman A., May C. et al. Fluoroquinolone resistance in Mycobacterium tuberculosis: an assessment of MGIT 960, MODS and nitrate reductase assay and fluoroquinolone cross-resistance // J. Antimicrob. Chemother. - 2009. - Vol. 63, N 6. - P. 1173-1178. |
| [16] |
Drlica K., Zhao X. DNA Gyrase, Topoisomerase IV, and the 4-Quinolones // Microbiol. Mol. Biol. Rev. - 1997. - Vol. 61, N 3. - P. 377-392. |
| [17] |
Engohang-Ndong J., Baillat D., Aumercier M. et al. EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator // Mol. Microbiol. - 2004. - Vol. 51, N 1. - P. 175- 188. |
| [18] |
Felnagle E. A., Rondon M. R., Berti A. D. et al. Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin // J. Antimicrob. Chemother. - 2007. - Vol. 73, N 13. - P. 4162-4170. |
| [19] |
Feng Z., Barletta R. G. Roles of Mycobacterium smegmatis D-Alanine: D-Alanine Ligase and D-Alanine Racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-Cycloserine // Antimicrob. Agents Chemother. - 2003. - Vol. 47, N 1. - P. 283-291. |
| [20] |
Feuerriegel S., Cox H. S., Zarkua N. et al. Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients, undergoing treatment // Antimicrob. Agents Chemother. - 2009. - Vol. 53, N 8. - P. 3353-3356. |
| [21] |
Giannoni F., Iona E., Sementilli F. et al. Evaluation of new line probe assay for rapid identification of gyr A mutations in Mycobacterium tuberculosis // J. Antimicrob. Chemother. - 2005. - Vol. 49, N 7. - P. 2928-2933. |
| [22] |
Herr E. B. Jr., Redstone M. O. Chemical and physical characterization of capreomycin // Ann. N. Y. Acad. Sci. - 1966. - Vol. 135. - P. 940-946. |
| [23] |
Hillemann D.,* Rusch-Gerdes S., Richter E. Feasibility of the Geno Type MTBDRsl assay for fluoroquinolone, amikacin-capreomycin, and ethambutol resistance testing of Mycobacterium tuberculosis strain and clinical specimens // J. Clin. Microbiol. - 2009. - Vol. 47, N 6. - P. 1767-1772. |
| [24] |
Ji B., Truffot-Pernot C., Lacroix C. et al. Effectiveness of rifampin, rifabutin, and rifapentine for preventive therapy of tubercolosis in mice // Am. Rev. Respir. Dis. - 1993. - Vol. 148. - P. 1541-1546. |
| [25] |
Johansen S. K., Maus C. E., Plikaytis B. B., Douthwaite S. Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 20-O-methylations in 16S and 23S rRNAs // Mol. Cell. - 2006. - Vol. 23. - P. 173-182. |
| [26] |
Johnson R., Streicher E. M., Louw G. E. et al. Drug resistance in Mycobacterium tuberculosis // Curr. Issues Mol. Biol. - 2005. - Vol. 8. - P. 97-112. |
| [27] |
Jugheli L., Bzekalava N., de Rijk P. et al. High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gent // Antimicrob. Agents Chemother. - 2009. - Vol. 53, N 12. - P. 5064- 5068. |
| [28] |
Kocagöz T., Hackbarth C. J., Unsal I. et al. Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra // J. Antimicrob. Chemother. - 1996. - Vol. 40, N 87. - P. 1768-1774. |
| [29] |
Koseki Y., Okamoto S. Studies on sross-resistance between capreomycin and certain other antimycobacterial agants // Jpn J. Med. Sci. Biol. - 1963. - Vol. 16. - P. 31-38. |
| [30] |
Larsen M. H., Vilchéze C., Kremer L. et al. Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis // Mol. Microbiol. - 2002. - Vol. 46, N 2. - P. 453-466. |
| [31] |
Marrakchi H., Laneelle G., Quemard A. InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II // Microbiology. - 2000. - Vol. 146. - P. 289-296. |
| [32] |
Mathys V., Wintjens R., Lefevre P. et al. Molecular genetics of paraaminosalicylie acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis // Antimicrob. Agents Chemother. - 2009. - Vol. 53, N 5. - P. 2100-2109. |
| [33] |
Maus C. E., Plikaytis B. B., Shinnick T. M. Molecular analysis cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis // Antimicrob. Agents Chemother. - 2005. - Vol. 49, N 8. - P. 3192-3197. |
| [34] |
Maus C. E., Plikaytis B. B., Shinnick T. M. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis // Antimicrob. Agents Chemother. - 2005. - Vol. 49, N 2. - P. 571-577. |
| [35] |
McClatchy J. K., Kanes W., Davidson P. T., Moulding T. S. Cross-resistance in M. tuberculosis to kanamycin, capreomycin and viomycin // Tubercle. - 1977. - Vol. 58. - P. 29-34. |
| [36] |
Mdluli K., Ma Z. Mycobacterium tuberculosis DNA gyrase as a target for drug discovery // Infect. Disord. Drug Targets. - 2007. - Vol. 7, N 2. - P. 159-168. |
| [37] |
Mokrousov I., Otten T., Manicheva O. et al. Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia // Antimicrob. Agents Chemother. - 2008. - Vol. 52, N 8. - P. 2937-2939. |
| [38] |
Morlock G. P., Metchock B., Sikes D. et al. EthA, inhA, and katG Loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates // Antimicrob. Agents Chemother. - 2003. - Vol. 47, N 12. - P. 3799-3805. |
| [39] |
Peteroy M., Severin A., Zhao F. et al. Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-Cycloserine and Vancomycin // Antimicrob. Agents Chemother. - 2000. - Vol. 44, N 6. - P. 1701-1704. |
| [40] |
Petry Jr. W. Chemotherapy of tuberculosis, mycobacterium avium complex disease and leprosy // Goodman & Gilman The pharmacological Basis of Therapeutics / Brunton L. L. et al. - 2006. - P. 1203-1223. |
| [41] |
Pitaksajjakul P., Wongwit W., Punprasit W. et al. Mutations in the gyrA and gyrB genes of fluoroquinolone-resistant Mycobacterium tuberculosis from TB patients in Thailand // Southeast Asian J. Trop. Med. Publ. Hlth. - 2005. - Vol. 36, N 4. - P. 228-237. |
| [42] |
Rengarajan J., Sassetti C. M., Naroditskaya V. et al. The folate pathway is a target for resistance to the drug para-aminosalicylie acid (PAS) in mycobacteria // Mol. Microbiol. - 2004. - Vol. 53, N 1. - P. 275-282. |
| [43] |
Shi R., Zhang J., Li C. et al. Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing // J. Clin. Microbiol. - 2006. - Vol. 44, N 12. - P. 4566-4568. |
| [44] |
Sreevatsan S., Pan X., Stockbauer K. E. et al. Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionary recent global dissemination // Proc. Natl Acal. Sci. USA. - 1997. - Vol. 94. - P. 9869- 9874. |
| [45] |
Sugawara I., Zhang J., Li C. Cross-resistance of Mycobacterium tuberculosis isolates among streptomycin, kanamycin and amikacin // Indian J. Exp. Biol. - 2009. - Vol. 47, N 6. - P. 520-522. |
| [46] |
Sun Z., Zhang J., Zhang X. et al. Comparison of gyrA gene mutations between laboratory-selected ofloxacin-resistant Mycobacterium tuberculosis strains and clinical isolates // Int. J. Antimicrob. Agents. - 2008. - Vol. 31. - P. 115-121. |
| [47] |
Sutton W. B., Gordee R. S., Wick W. E., Standfield L. V. In vitro and in vivo laboratory studies on the antituberculosis activity of capreomycin // Ann. N. Y. Acad. Sci. - 1966. - Vol. 135. - P. 947-959. |
| [48] |
Suzuki Y., Katsukawa C., Tamaru A. et al. Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene // J. Clin. Microbiol. - 1998. - Vol. 36, N 5. - P. 1220-1225. |
| [49] |
Taniguchi H., Chang B., Abe C. et al. Molecular analysis of kanamycin and viomycin resistance in Mycobacterium smegmatis by use of the conjugation system // J. Bacteriol. - 1997. - Vol. 179, N 15. - P. 4795-4801. |
| [50] |
Tsukamura M. Cross-resistance relationships between capreomycin, kanamycin and viomycin resistance in tubercle bacilli from patients // Am. Rev. Respir. Dis. - 1969. - Vol. 99. - P. 780-782. |
| [51] |
Tyagi J. S., Sharma D. Mycobacterium smegmatis and tuberculosis // Trends Microbiol. - 2002. - Vol. 10, N 2. - P. 68- 69. |
| [52] |
Uzun M., Erturan Z. O. An investigation of cross-resistance between rifampin and rifabutin in Mycobacterium tuberculosis complex strains // J. Tuberc. Lung Dis. - 2002. - Vol. 6, N 2. - P. 164-165. |
| [53] |
Vilchéze C., Weisbrod T. R., Chen B. et al. Altered NADH/ NAD+ ratio mediates coresistance to isoniazid and ethionamide in Mycobacteria // Antimicrob. Agents Chemother. - 2005. - Vol. 49, N 2. - P. 708-720. |
| [54] |
Vilchéze C., Av-Gay Y., Attarian R. et al. Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis // Mol. Microbiol. - 2008. - Vol. 69, N 5. - P. 1316-1329. |
| [55] |
Wang J. C. DNA topoisomerases // Annu. Rev. Biochem. - 1985. - Vol. 54. - P. 665-597. |
| [56] |
Wang J.-Y., Lee L.-N., Lai H.-C. et al. Fluoroquinolone resistance in Mycobacterium tuberculosis isolates: associated genetic mutations and relationship to antimicrobial exposure // J. Antimicrob. Chemother. - 2007. - Vol. 59. - P. 860-865. |
| [57] |
Wargel R. J., Shadur C. A., Neuhaus F. C. Mechanism of D-Cycloserine action: transport mutants for D-Alanine, D-Cycloserine, and Glycinel // J. Bacteriol. - 1971. - Vol. 105, N 3. - P. 1028-1035. |
| [58] |
Winder F. G., Collins P. B., Whelan D. Effects of ethionamide and isoxyl on mycolic acid synthesis in Mycobacterium tuberculosis BCG // J. Gen. Microbiol. - 1971. - Vol. 68. - P. 1037-1044. |
| [59] |
Xu P., Li X., Zhao M. et al. Prevalence of fluoroquiolone resistance among tuberculosis patients in Shanghai, China // J. Antimicrob. Chemother. - 2009. - Vol. 53, N 7. - P. 3170-3172. |
| [60] |
Yang B., Koga H., Ohno H. et al. Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis // J. Antimicrob. Chemother. - 1998. - Vol. 42, N 5. - P. 621-628. |
| [61] |
Zhang Y. The magic bullets and tuberculosis drug targets // Annu. Rev. Pharmacol. Toxicol. - 2005. - Vol. 45. - P. 529- 564. |
Eco-vector
/
| 〈 |
|
〉 |