Regularities of changes in laboratory parameters in patients with A/H1N1 influenza pneumonia

Elena Nikolaevna Romanova; Ol'ga Mikhaylovna Serebryakova; Anatoliy Vasil'evich Govorin; Andrey Petrovich Filev; E N Romanova; O M Serebryakova; A V Govorin; A P Filev

doi:10.17816/EID40561

Epidemiology and Infectious Diseases ›› 2011, Vol. 16 ›› Issue (4) : 23 -27. DOI: 10.17816/EID40561

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Regularities of changes in laboratory parameters in patients with A/H1N1 influenza pneumonia

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Abstract

The medical records of 97 patients with A/H1N1 influenza pneumonia were analyzed. The important feature of the disease is a high risk of fatal outcomes, the direct cause of which is acute respiratory distress syndrome (ARDS). The most significant abnormalities of laboratory values were noted in this category of patients. In ARDS, leukopenia or normocytosis changed to leukocytosis, which is attributed to massive bacterial infection. These patients were also recorded to have immunodeficiency-induced lymphopenia and disseminated intravascular coagulation-induced thrombocytopenia. The marked elevation of transaminases mainly due to asparagine transaminase and the increase of creatine phosphokinase suggest that the most severe category of patients has rhabdomyolysis. Characteristic of this was a reactive rise of amylase. In ARDS, diminished renal functional capacity reflected the higher blood levels of creatinine and urea.

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community-acquired pneumonia / A/H1N1 influenza / acute lung injury / acute respiratory distress syndrome

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Elena Nikolaevna Romanova, Ol'ga Mikhaylovna Serebryakova, Anatoliy Vasil'evich Govorin, Andrey Petrovich Filev, E N Romanova, O M Serebryakova, A V Govorin, A P Filev. Regularities of changes in laboratory parameters in patients with A/H1N1 influenza pneumonia. Epidemiology and Infectious Diseases, 2011, 16(4): 23-27 DOI:10.17816/EID40561

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