Extrapulmonary sarcoidosis during antiviral therapy for chronic hepatitis C

Abstract

The spectrum of adverse reactions caused by combined interferon therapy includes the development of autoimmune diseases, including sarcoidosis. Extrapulmonary sarcoidosis is its rare form. The paper describes a case of extrapulmonary sarcoidosis in a young woman at 28 weeks of combined interferon therapy for chronic hepatitis C 1b genotype. Corticosteroid therapy led to remission with the retention of a sustained virological response to antiviral therapy.

Keywords

chronic hepatitis C / treatment / interferon preparations / adverse reactions of combined antiviral therapy / extrapulmonary sarcoidosis / corticosteroid therapy

References

[1] Анисимов Л. А. Поражение печени при саркоидозе: Автореф. дис. ... канд. мед. наук. - М., 1987.

[2] Bolukbas C., Bolukbas F. F., Kebdir T. et al. Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C - a case report and review of the literature // Acta Gastroenterol. Belg. - 2005. - Vol. 68, N 4. - P. 432-434.

[3] Cacoub P., Sbai A., Frances C. et al. Systemic sarcoidosis during interferon-alpha therapy for chronic hepatitis C virus infection // Gastroenterol. Clin. Biol. - 2000. - Vol. 24. - P. 364- 366.

[4] Celik G., Sen E., Ulger A. F. et al. Sarcoidosis caused by interferon therapy // Respirology. - 2005. - Vol. 10, N 4. - P. 535-540.

[5] Goncales F. L. Jr. et al. Weight-based combination therapy with peginterferon alpha-2b and ribavirin for Naive, relapser and non-responder patients with chronic hepatitis C // Braz. J. Infect. Dis. - 2006. - Vol. 10, N 5. - P. 311-316.

[6] Hoffmann R. M., Jung M.-C., Motz R. et al. Sarcoidosis associated with interferon-α therapy for chronic hepatitis C // J. Hepatol. - 1998. - Vol. 28. - P. 1058-1063.

[7] Hurst E. A., Mauro T. Sarcoidosis associated with pegylated interferon alfa and ribavirin treatment for chronic hepatitis C: a case report and review of the literature // Arch. Dermatol. - 2005. - Vol. 141, N 7. - P. 865-868.

[8] Michavila I. A., Sanchez M. M., Ronchel P. et al. Sarcoidosis following combined ribavirin and interferon therapy: a case report and review of the literature // Arch. Bronconeumol. - 2004. - Vol. 40. - P. 45-49.

[9] Perez-Alvarez R., Perez-Lopez R., Lombrana J. L. et al. Sarcoidosis in two patients with chronic hepatitis C treated with interferon, ribavirin and amantadine // J. Viral Hepatit. - 2002. - Vol. 9. - P. 75-79.

[10] Ramos-Casals M., Mana J., Nardi N. et al. Sarcoidosis in patients with chronic hepatitis C virus infection: analysis of 68 cases // Medicine (Baltimore). - 2005. - Vol. 84, N 2. - P. 69- 80.

[11] Schiff E. R. Emerging strategies for pegylated interferon combination therapy // Nat. Clin. Pract. Gastroenterol. Hepatol. - 2007. - Vol. 4, Suppl. 1. - P. S17-S21.

[12] Tae-Hun Kim, Jong-Eun Joo. Spontaneous resolution of systemic sarcoidosis in a patient with chronic hepatitis C without interferon therapy // Wld J. Gastroenterol. - 2006. - Vol. 12. - P. 150-153.

[13] Tortorella C., Napoli N., Panella E. et al. Asymptomatic systemic sarcoidosis arising 5 years after IFN-alpha treatment for chronic hepatitis C: a new challenge for clinicans // J. Interferon Cytokine Res. - 2004. - Vol. 24, N 11. - P. 655-658.

[14] Yamada S., Mine S., Fujisaki T. et al. Hepatic sarcoidosis assosiated with chronic hepatitis C // J. Gastroenterol. - 2002. - Vol. 37. - P. 564-570.

RIGHTS & PERMISSIONS

Eco-vector