Mechanisms of an exacerbation of hepatitis B and C in the presence of opisthorchiasis

V G Bychkov; G G Krylov; N A Efimova; Vladimir Vasil'evich Mefod'ev; A Kh Sabirov; A M Ibragimova; E D Khadieva; V G Bychkov; G G Krylov; N A Yefimova; V V Mefodyev; A Kh Sabirov; A M Ibragimova; Ye D Khadiyeva

doi:10.17816/EID40478

Epidemiology and Infectious Diseases ›› 2010, Vol. 15 ›› Issue (2) : 34 -38. DOI: 10.17816/EID40478

Articles

other

Mechanisms of an exacerbation of hepatitis B and C in the presence of opisthorchiasis

Author information +

Tyumen State Medical Academy, Russian Agency for Health Care

Therapeutic Health Center, OOO TyumenNIIgiprogaz, Tyumen

Molecular Genetic Diagnostic Center, Tyumen

Khanty-Mansiysk District Clinical Hospital

Tyumen State Medical Academy, Russian Agency for Health Care

Therapeutic Health Center, OOO TyumenNIIgiprogaz, Tyumen

Molecular Genetic Diagnostic Center, Tyumen

Tyumen State Medical Academy, Russian Agency for Health Care

Khanty-Mansiysk District Clinical Hospital

Show less

History +

PDF

Abstract

The authors made clinical, immunological, biochemical, molecular genetic, and morphological analyses of the course of chronic hepatitis (CH) B and C concurrent with opisthorchiasis and without infestation.It was found that in parasitocenoses, pain, astheno-vegetative, dyspeptic, asthenic, and hepatomegalic syndromes were 2.0-3.3 times more frequently observed; the values of ALT, AST, thymol test, and alkaline phosphatase were significantly increased; the level of cholesterol decreased. The immune system exhibited disorganization and depression of humoral and cellular links. A morphological study of liver biopsy specimens by the Knodell scale revealed significantly enhanced hepatocyte destructive processes, alleviated immune-mediated inflammation, and obvious pericellular sclerosis of hepatocytes and sinusoidal capillaries, which substantially impaired the trophics of the liver parenchyma and stimulated apoptosis and necrosis. Virus gene mutations were seen.The severe course of CH concurrent with opisthorchiasis is attributable to more pronounced destructive processes and hypoxia of hepatocytes. Mutations of "responsible" genes are more frequently responsible for hepatocellular carcinoma.

Keywords

chronic hepatitis / opisthorchiasis

Cite this article

Download citation ▾

V G Bychkov, G G Krylov, N A Efimova, Vladimir Vasil'evich Mefod'ev, A Kh Sabirov, A M Ibragimova, E D Khadieva, V G Bychkov, G G Krylov, N A Yefimova, V V Mefodyev, A Kh Sabirov, A M Ibragimova, Ye D Khadiyeva. Mechanisms of an exacerbation of hepatitis B and C in the presence of opisthorchiasis. Epidemiology and Infectious Diseases, 2010, 15(2): 34-38 DOI:10.17816/EID40478

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Белобородова Э. И., Шаловой А. Л. Сиб. журн. гастроэнтерол. и гепатол. - 1995. - № 8. - С. 22-24.

[2]	Болезни печени и желчевыводящих путей: Руководство для врачей / Гл. ред. В. Т. Ивашкин. - М., 2002.

[3]	Бычков В. Г., Крылов Г. Г., Мефодьев В. В. и др. // Int. J. Immunorehabil. - 2002. - Vol. 4, N 1. - P. 48.

[4]	Бычков В. Г., Сергиев В. П., Сабиров А. Х. и др. // Мед. паразитол. - 2007. - № 2. - С. 3-6.

[5]	Крылов Г. Г. Суперинвазионный описторхоз: пато- и морфогенез осложненных форм и микстпатологии: Автореф. дис. ... д-ра мед. наук. - М., 2005.

[6]	Лепехин А. В., Мефодьев В. В., Филатов В. Г., Бужак Н. С. Эпидемиология, клиника и профилактика описторхоза. - Томск, 1992.

[7]	Мефодьев В. В., Ефимова Н. А., Бычков В. Г. // Материалы IX съезда Всероссийского науч.-практ. о-ва эпидемиологов, микробиологов, паразитологов. - М., 2007. - Т. 1. - С. 356-357.

[8]	Соколов С. А. Клинико-патогенетические взаимосвязи иммунологических и биохимических показателей у больных хроническим вирусным гепатитом в сочетании с описторхозом: Автореф. дис. ... канд. мед. наук. - Тюмень, 2002.

[9]	Шерлок Ш., Дули Дж. Заболевания печени и желчных путей: Пер. с англ. под ред. З. П. Апросиной, Н. А. Мухина. - М., 2002.