Role of vaccination against pneumococcal and influenza infections in the clinical course of type 1 diabetes in children and adolescents
M P Kostinov , T V Skochilova , V A Vorob'eva , A A Tarasova , T I Korovkina , Igor' Viktorovich Lukachev , I Yu Yushkova , M P Kostinov , T V Skochilova , V A Vorobyeva , A A Tarasova , T I Korovkina , I V Lukachev , I Yu Yushkova
Epidemiology and Infectious Diseases ›› 2010, Vol. 15 ›› Issue (2) : 18 -22.
Role of vaccination against pneumococcal and influenza infections in the clinical course of type 1 diabetes in children and adolescents
The impact of vaccination against pneumococcal infection with 100 Pneumo 23 vaccine (n = 72) and with this vaccine in combination with the subunit vaccine Grippol against influenza (n = 28) was studied in children and adolescents with type 1 diabetes mellitus (DM). A control group consisted of 30 unvaccinated children with type 1 DM. All the children received intensified insulin therapy with human insulin preparations for an average of 0.88±0.03 U/kg/day. Vaccination was made in 59% in the compensation phase of type 1 DM and in its subcompensation phase in 41%. Mono- and combined vaccinations were ascertained to result in DM stabilization. Within a year after administration of pneumococcal vaccine, the incidence rates of acute respiratory infections (ARI) reduced by 2.2 times, and that of ARI concurrent with laryngotracheitis, otitis, and maxillary sinusitis decreased by 2.3, 1.6, and 4 times, respectively. With combined vaccination against pneumococcal and influenza infection in children and adolescents with type 1 DM, these rates showed 1.6-, 1.6-, 4.6-, and 2.3-fold reductions, respectively. The duration and severity of ARI were significantly reduced. Accordingly, the frequency of using antibiotic therapy was decreased by 3.6 times in the Pneumo 23 group and by 3.9 times in the combined vaccination group. The control group demonstrated no positive changes in the incidence, severity, and complications of ARE. It is suggested that administration of pneumococcal polysaccharide vaccine yields a therapeutic effect in patients with type DM.
type 1 diabetes / children and adolescents / vaccination against pneumococcal infection and influenza / acute respiratory infections / complications / postvaccinal period
| [1] |
Геппе Н. А., Малахова А. Б. Пневмококковая инфекция респираторной системы в детском возрасте. - М., 2005. - С. 26-27, 40-49. |
| [2] |
Гольдштейн А. В. // Вакцинация. Новости вакцинопрофилакт. - 2004. - № 2 (32). - С. 10-11. |
| [3] |
Сахарный диабет у детей и подростков / Дедов И. И. и др. - М., 2002. |
| [4] |
Костинов М. П., Гурвич Э. Б. Вакцины нового поколения в профилактике инфекционных заболеваний. - М., 2002. - С. 9-17, 45-51, 118-141. |
| [5] |
От профилактического к терапевтическому эффекту вакцин против пневмококковой и гемофильной типа b инфекций у пациентов с бронхолегочной патологией / Под ред. М. П. Костинова. - М., 2007. |
| [6] |
Синопальников А. И., Козлов Р. С., Белоцерковская Ю. Г. // Чучалин А. Г., Синопальников А. И., Чернеховская Н. Е. Пневмония. - М., 2002. - С. 405-421. |
| [7] |
Смирнов В. В. и др. // Педиатрия. - 1992. - № 2. - С. 28- 32. |
| [8] |
Immunization and the Prevention of Influenza and Pneumococcal Disease in People With Diabetes. - New-York, 2003. - P. 126-128. |
| [9] |
Recommendations of the Advisory Committee on Immunization Practices (ACIP) and the American Academy of Family Physicians (AAFP): General Recommendations on Immunization / Prepared by William L. [et al.] // Recommendat. and Rep. - 2002. - Vol. 51, N RR02. - Р. 1-36. |
| [10] |
Standards of Medical Care for Patients With Diabetes Mellitus. // Clin. Diabet. - 2003. - Vol. 21. - Р. 27-37. |
Eco-vector
/
| 〈 |
|
〉 |
PDF
