Age-related clinical and epidemiological features of meningococcal infection in children and ways of improving therapy

Natal'ya Viktorovna Skripchenko; Yu V Lobzin; L A Alekseeva; M V Ivanova; A A Vil'nits; V V Karasev; G P Ivanova; E Yu Gorelik; N F Pul'man; A S Kvetnaya; M O Volkova; K O Shevchenko; N V Skripchenko; Yu V Lobzin; L A Alekseyeva; M V Ivanova; A A Vilnits; V V Karasev; G P Ivanova; Ye Yu Gorelik; N F Pulman; A S Kvetnaya; M O Volkova; K O Shevchenko

doi:10.17816/EID40448

Epidemiology and Infectious Diseases ›› 2010, Vol. 15 ›› Issue (1) : 35 -40. DOI: 10.17816/EID40448

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Age-related clinical and epidemiological features of meningococcal infection in children and ways of improving therapy

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Research Institute of Childhood Infections, Federal Biomedical Agency

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Abstract

The paper presents a clinical and laboratory analysis of generalized forms of meningococcal infection (MI) in 90 patients aged 1 month to 18 years. The age-related features of the disease under the present conditions and a relationship of its clinical manifestations to the serogroup of a meningococcus are determined. The implication of endogenous intoxication, proteolysis and a systemic inflammatory reaction in the pathogenesis of MI is established. The expediency of co-administration of antibacterial drugs and systemic enzymes and prolonged infusion therapy for generalized forms of MI is scientifically founded and the efficiency of the proposed therapeutic tactics is proven.

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children / meningococcal infection / meningitides / endogenous toxins / C-reactive protein / proteolysis / systemic enzymes

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Natal'ya Viktorovna Skripchenko, Yu V Lobzin, L A Alekseeva, M V Ivanova, A A Vil'nits, V V Karasev, G P Ivanova, E Yu Gorelik, N F Pul'man, A S Kvetnaya, M O Volkova, K O Shevchenko, N V Skripchenko, Yu V Lobzin, L A Alekseyeva, M V Ivanova, A A Vilnits, V V Karasev, G P Ivanova, Ye Yu Gorelik, N F Pulman, A S Kvetnaya, M O Volkova, K O Shevchenko. Age-related clinical and epidemiological features of meningococcal infection in children and ways of improving therapy. Epidemiology and Infectious Diseases, 2010, 15(1): 35-40 DOI:10.17816/EID40448

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