Measles immunity in medical workers in Kazan

Abstract

BACKGROUND: The epidemiological situation with measles remains unstable, with periodic increases in morbidity. In the Russian Federation, as well as in other countries, cases of nosocomial infection continue to be registered. Medical workers may be involved in the epidemic process and serve, among other things, as a source of infection for patients.

AIMS: assessment of postvaccinal immunity to measles in medical workers in Kazan during its elimination period.

MATERIALS AND METHODS: A cross-sectional study of immunity to measles was conducted in 515 employees of medical institutions in Kazan. 376 medical staff had documented ever-evidence of immunization against measles. Measles class G immunoglobulin levels were determined, specific immunity strength was assessed as a function of age, and time since the last vaccine dose was administered. Relative values (fractions, %) and standard error of the fraction (%) were calculated. A correlation analysis was performed.

RESULTS: The proportion of seropositive medical workers was 81% (95% CI 79.3–82.7) of all those examined. Those over 50 years of age were the most protected: antibodies were detected in 90.3% (95% CI 85.96–94.64) of them. Among the 417 persons with antibodies low level was detected in 60.9% (95% CI 56.12–65.68), medium level ― in 34.5% (95% CI 29.84–39.16), high level ― only in 4.6% (95% CI 2.54–6.66) of the examined persons. In all age groups, the share of persons with low levels of protective antibodies was the highest. High level of protective antibodies was registered only in the age groups 40–49 years and 50 years and older ― 4.8% (95% CI 0.98–8.62) and 7% (95% CI 3.26–10.74), respectively. Antibody levels correlated inversely with time since vaccination (p <0.05).

CONCLUSIONS: The results of serologic study of health workers demonstrate insufficient protection of health workers against measles, especially in younger groups. Decreased immunity in vaccinated health workers 10 or more years after immunization necessitates the monitoring of antibody levels in this group and consideration of revaccination.

Keywords

measles elimination / antibodies / immunity / medical workers / age

References

[1] Aleshkin VA, Tikhonova NT, Gerasimova AG, et al. Problems towards Measles elimination in Rassian Federation. J Microbiol Epidemiol Immunobiol. 2016;(5):29–34. (In Russ). doi: 10.36233/0372-9311-2016-5-29-34

[2] Алешкин В.А., Тихонова Н.Т., Герасимова А.Г., и др. Проблемы на пути достижения элиминации кори в Российской Федерации // Журнал микробиологии, эпидемиологии и иммунобиологии. 2016. № 5. С. 29–34. doi: 10.36233/0372-9311-2016-5-29-34

[3] Tsvirkun OV, Tihonova NT, Yushchenko GV, Gerasimova AG. Measles epidemic process in various vaccinal periods. Epidemiol Vaccinal Prevention. 2015;14(2):80–87. (In Russ). doi: 10.31631/2073-3046-2015-14-2-80-87

[4] Цвиркун О.В., Тихонова Н.Т., Ющенко Г.В., Герасимова А.Г. Эпидемический процесс кори в разные периоды ее вакцинопрофилактики // Эпидемиология и вакцинопрофилактика. 2015. Т. 14, № 2. С. 80–87. doi: 10.31631/2073-3046-2015-14-2-80-87

[5] Yunasova TN, Gorenkov DV, Rukavishnikov AV, et al. Analysis of measles incidence in russia and problems of measles prevention at the elimination stage. BIOpreparations Prevention Diagnosis Treatment. 2019; 19(3):154–160. (In Russ). doi: 10.30895/2221-996X-2019-19-3-154-160

[6] Юнасова Т.Н., Горенков Д.В., Рукавишников А.В., и др. Анализ заболеваемости корью в России и проблемы профилактики кори на этапе элиминации // БИОпрепараты. Профилактика, диагностика, лечение. 2019. Т. 19, № 3. С. 154–160. doi: 10.30895/2221-996X-2019-19-3-154-160

[7] On the state of sanitary and epidemiological well-being of the population in the Russian Federation at 2019: State report. Moscow: Federal Service for Supervision of Consumer Rights Protection and Human Wellbeing; 2020. Р. 172–174. (In Russ).

[8] О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2019 году: государственный доклад. Москва: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2020. С. 172–174.

[9] Nozdracheva AV, Semenenko ТА. The status of herd immunity to measles in Russia: A systematic review and meta-analysis of epidemiological studies. J Microbiol Epidemiol Immunobiol. 2020;(5):445–457. (In Russ). doi: 10.36233/0372-9311-2020-97-5-7

[10] Ноздрачева А.В., Семененко Т.А. Состояние популяционного иммунитета к кори в России: систематический обзор и метаанализ эпидемиологических исследований // Журнал микробиологии, эпидемиологии и иммунобиологии. 2020. Т. 97, № 5. С. 445–457. doi: 10.36233/0372-9311-2020-97-5-7

[11] Toptygina AP, Smerdova MA, Naumova MA, et al. Influence of population immunity peculiarities on the structure of Measles and Rubella prevalence. Infection Immunity. 2018;8(3):341–348. (In Russ). doi: 10.15789/2220-7619-2018-3-341-348

[12] Топтыгина А.П., Смердова М.А., Наумова М.А., и др. Влияние особенностей популяционного иммунитета на структуру заболеваемости корью и краснухой // Инфекция и иммунитет. 2018. Т. 8, № 3. С. 341–348. doi: 10.15789/2220-7619-2018-3-341-348

[13] Smerdova MA, Toptygina AP, Andreev YuYu, et al. Humoral and cellular immunity to measles and rubella virus antigens in healthy subjects. Infection Immunity. 2019;9(3-4):607–611. (In Russ). doi: 10.15789/2220-7619-2019-3-4-607-611

[14] Смердова М.А., Топтыгина А.П., Андреев Ю.Ю., и др. Гуморальный и клеточный иммунитет к антигенам вирусов кори и краснухи у здоровых людей // Инфекция и иммунитет. 2019. Т. 9. № 3-4. С. 607–611. doi: 10.15789/2220-7619-2019-3-4-607-611

[15] On the state of sanitary and epidemiological well-being of the population in the Russian Federation at 2020: State report. Moscow: Federal Service for Supervision of Consumer Rights Protection and Human Wellbeing; 2021. Р. 159–161. (In Russ).

[16] О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2020 году: государственный доклад. Москва: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2021. С. 159–161.

[17] Vagholkar S, Ng J, Chan RC, et al. Healthcare workers and immunity to infectious diseases. Aust N Z J Public Health. 2008;32(4):367–371. doi: 10.1111/j.1753-6405.2008.00257.x

[18] Vagholkar S., Ng J., Chan R.C., et al. Healthcare workers and immunity to infectious diseases // Aust N Z J Public Health. 2008. Vol. 32, N 4. Р. 367–371. doi: 10.1111/j.1753-6405.2008.00257.x

[19] Kostinov MP, Filatov N, Zhuravlev PI, et al. Level of measles herd immunity assessed in hospital medical workers within a framework of the state measles elimination program. Infection Immunity. 2020;10(1):129–136. (In Russ). doi: 10.15789/2220-7619-LOM-690

[20] Костинов М.П., Филатов Н.Н., Журавлев П.И., и др. Уровень коллективного иммунитета к вирусу кори у сотрудников отдельной больницы в рамках государственной элиминации кори // Инфекция и иммунитет. 2020. Т. 10, № 1. С. 129–136. doi: 10.15789/2220-7619-LOM-690

[21] Avdonina LG, Patyashina MA, Isaeva GS, et al. Collective Immunity to Virus Measles of Medical Workers and Students of Medical Colleges in the Republic of Tatarstan. Epidemiol Vaccinal Prevent. 2019;18(1):43–49. (In Russ). doi: 10.31631/2073-3046-2019-18-1-43-49

[22] Авдонина Л.Г., Патяшина М.А., Исаева Г.Ш., и др. Коллективный иммунитет к вирусу кори у медицинских работников и студентов медицинских колледжей в Республике Татарстан // Эпидемиология и вакцинопрофилактика. 2019. Т. 18, № 1. С. 43–49. doi: 10/31631/2073-3046-2019-18-1-43-49

[23] Sarmometov EV, Mokova NM, Voldshmidt NB, et al. Evaluation of measles immunity intensity among medical workers in the City Perm. Epidemiol Vaccinal Prevent. 2011;(4):45–48. (In Russ).

[24] Сармометов Е.В., Мокова Н.М., Вольдшмидт Н.Б., и др. Оценка напряжённости противокоревого иммунитета у медицинских работников г. Перми // Эпидемиология и вакцинопрофилактика. 2011. № 4. С. 45–48.

[25] Krieger EA, Samodova OV. Measles humoral immunity in health-care workers. Infection Immunity. 2021;11(3):523–529. (In Russ). doi: 10.15789/2220-7619-HIT-1452

[26] Кригер Е.А., Самодова О.В. Гуморальный иммунитет к кори у медицинских работников // Инфекция и иммунитет. 2021. Т. 11, № 3. С. 523–529. doi: 10.15789/2220-7619-HIT-1452

[27] Volyanskiy A, Klisa A, Kuchma M, et al. Evaluation of an immunity status against measles of health workers in Kharkiv city. J V.N. Karazin Kharkiv National University, Series Medicine. 2019;(38):72–78. doi: 10.26565/2313-6693-2019-38-09

[28] Volyanskiy A., Klisa A., Kuchma M., et al. Evaluation of an immunity status against measles of health workers in Kharkiv city // J V.N. Karazin Kharkiv National University, Series Medicine. 2019. N 38. P. 72–78. doi: 10.26565/2313-6693-2019-38-09

[29] Belopolskaya MA, Grigoryeva TD, Avrutin VYu, et al. Measles immunity in different population groups. J Infectology. 2020;12(1): 80–84. (In Russ). doi: 10.22625/2072-6732-2020-12-1-80-84

[30] Белопольская М.А., Григорьева Т.Д., Аврутин В.Ю., и др. Напряженность иммунитета к кори в различных группах населения // Журнал инфектологии. 2020. Т. 12, № 1. С. 80–84. doi: 10.22625/2072-6732-2020-12-1-80-84

[31] Bianchi FP, Stefanizzi P, Nittos D, et al. Long-term Immunogenicity of measles vaccine: an italian retrospective cohort study. J Inf Dis. 2020;221(5):721–728. doi: 10.1093/infdis/jiz508

[32] Bianchi F.P., Stefanizzi P., Nittos D., et al. Long-term immunogenicity of measles vaccine: an Italian retrospective cohort study // J Inf Dis. 2020. Vol. 221, N 5. P. 721–728. doi: 10.1093/infdis/jiz508

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