INTRATUMORAL STROMAL MAST CELLS IN RENAL CELL CARCINOMA: CLINICAL AND MORPHOLOGICAL COMPARISONS

Abstract

In the work there was investigated the prognostic value of the counting of intratumoral stromal mast cells (MC) in renal cell carcinoma. Tissue samples were obtained intraoperatively from 63 patients with renal cell carcinoma. The average age of patients accounted for 58.2 ± 12 years. There were observed 34 (54%) men and 29 (46%) women. There were revealed correlation relationships between the density of distribution of mast cells in tumor and the clinical stage of the disease (r = 0.69; p = 0.0001), tumor nodule size (r = 0.58; p = 0.0001), the presence of regional and distant metastases (r = 0.48; p = 0.0001), tumor grade according to the criteria of Fuhrman (r = 0.89; p = 0.001), and postoperative survival of patients (r = 0.40; p = 0.001). There was found no interrelationship between the number of MC in tumor with the gender (r = -0.03; p = 0.8), age (r = -0.15; p= 0.25), and the histological type of tumor (r = 0.16; p = 0.19). The gain in the number of intratumoral stromal MC in carcinoma can be considered as a predictor of the possible appearance of metastases. The high amount of MC in tumor has been shown to correlate with a poor prognosis of the patients with renal cell carcinoma.

Keywords

renal cell carcinoma / mast cell / prognosis

References

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