Merkel cell carcinoma with adrenal metastasis: a clinical case
Dina V. Rebrova , Yuliya A. Malyshenko , Tatyana V. Savelyeva , Liudmila A. Rudyuk , Аleksandr Е. Mityukov , Еkaterina S. Ivonina , Irina V. Soroko , Roman A. Chernikov , Ilya V. Sleptsov , Natalya V. Vorokhobina
Russian Journal of Oncology ›› 2023, Vol. 28 ›› Issue (3) : 145 -154.
Merkel cell carcinoma with adrenal metastasis: a clinical case
Merkel cell carcinoma is a rare primary malignant skin tumor with epithelial and neuroendocrine differentiation, which is usually characterized by an aggressive course with frequent local recurrence and a high metastatic potential. This article presents a clinical case of diagnosing Merkel cell carcinoma with secondary lesions of the adrenal glands, which is a rare localization of distant metastasis of this tumor with a low survival prognosis. Merkel cell carcinoma is difficult to diagnose due to its rare occurrence and can be mistaken for another dermatological disease. The patient's medical history was analyzed, starting from the outpatient stage of medical care until hospitalization for diagnostic surgery. The article is valuable for doctors of any specialty due to the difficulties in differential diagnosis of adrenal incidentalomas.
Merkel cell carcinoma / neuroendocrine tumor / neuroendocrine cancer / skin cancer / case report
| [1] |
Merkel cell carcinoma. Clinical guidelines. ID 297. Approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation. 2019. Available from: https://cr.minzdrav.gov.ru/recomend/297_1 (In Russ) |
| [2] |
Клинические рекомендации — Карцинома Меркеля. ID 297. Одобрено Научно-практическим Советом Минздрава РФ. 2019. Режим доступа: https://cr.minzdrav.gov.ru/recomend/297_1 Дата обращения: 01.01.2023 |
| [3] |
Utyashev IA, Orlova KV, Zinov’ev GV, et al. Practical recommendations for drug treatment of malignant non-melanocytic skin tumors (basal cell skin cancer, squamous cell skin cancer, Merkel cell carcinoma). Zlokachestvennye opukholi. 2022;12(3):672–696. (In Russ). EDN: OAZKFI doi: 10.18027/2224-5057-2022-12-3s2-672-696 |
| [4] |
Утяшев И.А., Орлова К.В., Зиновьев Г.В., и др. Практические рекомендации по лекарственному лечению злокачественных немеланоцитарных опухолей кожи (базальноклеточный рак кожи, плоскоклеточный рак кожи, карцинома Меркеля) // Злокачественные опухоли. 2022. Т. 12, № 3. С. 672–696. EDN: OAZKFI doi: 10.18027/2224-5057-2022-12-3s2-672-696 |
| [5] |
Hernandez LE, Mohsin N, Yaghi M, et al. Merkel cell carcinoma: An updated review of pathogenesis, diagnosis, and treatment options. Dermatol Ther. 2022;35(3):e15292. doi: 10.1111/dth.15292 |
| [6] |
Hernandez L.E., Mohsin N., Yaghi M., et al. Merkel cell carcinoma: An updated review of pathogenesis, diagnosis, and treatment options // Dermatol Ther. 2022. Vol. 35, N 3. P. e15292. doi: 10.1111/dth.15292 |
| [7] |
Albores-Saavedra J, Batich K, Chable-Montero F, et al. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol. 2010;37(1):20–27. doi: 10.1111/j.1600-0560.2009.01370.x |
| [8] |
Albores-Saavedra J., Batich K., Chable-Montero F., et al. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study // J Cutan Pathol. 2010. Vol. 37, N 1. P. 20–27. doi: 10.1111/j.1600-0560.2009.01370.x |
| [9] |
Ermilov VV, Zagrebin VL, Barkanov VB, Markelov VV, Mikailzade GF. Morphological features and modern strategies of treatment of Merkel cell carcinoma. Journal of Volgograd State Medical University. 2020;1(73):3–9. EDN: GVPRKM doi: 10.19163/1994-9480-2020-1(73)-3-9 |
| [10] |
Ермилов В.В., Загребин В.Л., Барканов В.Б., Маркелов В.В., Микаилзаде Г.Ф. Морфологические особенности и современные стратегии лечения карциномы Меркеля // Вестник ВолГМУ. 2020. Т. 1, № 73. С. 3–9. EDN: GVPRKM doi: 10.19163/1994-9480-2020-1(73)-3-9 |
| [11] |
Heath M, Jaimes N, Lemos B, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the “AEIOU” features. J Am Acad Dermatol. 2008;58(3):375–381. doi: 10.1016/j.jaad.2007.11.020 |
| [12] |
Heath M., Jaimes N., Lemos B., et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the “AEIOU” features // J Am Acad Dermatol. 2008. Vol. 58, N 3. P. 375–381. doi: 10.1016/j.jaad.2007.11.020 |
| [13] |
Skelton HG, Smith KJ, Hitchcock CL, et al. Merkel cell carcinoma: Analysis of clinical, histologic, and immunohistologicfeatures of 132 cases with relation to survival. J Amer Acad Dermatol. 1997;37(5 Pt 1): 734–739. doi: 10.1016/s0190-9622(97)70110-5 |
| [14] |
Skelton H.G., Smith K.J., Hitchcock C.L., et al. Merkel cell carcinoma: Analysis of clinical, histologic, and immunohistologicfeatures of 132 cases with relation to survival // J Amer Acad Dermatol. 1997. Vol. 37, N 5 Pt 1. P. 734–739. doi: 10.1016/s0190-9622(97)70110-5 |
| [15] |
Ren MY, Shi YJ, Lu W, et al. Facial Merkel cell carcinoma in a patient with diabetes and hepatitis B: А сase report. World J Clin Cases. 2023;11(17):4179–4186. doi: 10.12998/wjcc.v11.i17.4179 |
| [16] |
Ren M.Y., Shi Y.J., Lu W., et al. Facial Merkel cell carcinoma in a patient with diabetes and hepatitis B: А сase report // World J Clin Cases. 2023. Vol. 11, N 17. P. 4179–4186. doi: 10.12998/wjcc.v11.i17.4179 |
| [17] |
Tetzlaff MT, Harms PW Danger is only skin deep: Aggressive epidermal carcinomas. An overview of the diagnosis, demographics, molecular-genetics, staging, prognostic biomarkers, and therapeutic advances in Merkel call carcinoma. Mod Pathol. 2020;33:42–55. doi: 10.1038/s41379-019-0394-6 |
| [18] |
Tetzlaff M.T., Harms P.W. Danger is only skin deep: Aggressive epidermal carcinomas. An overview of the diagnosis, demographics, molecular-genetics, staging, prognostic biomarkers, and therapeutic advances in Merkel call carcinoma // Mod Pathol. 2020. Vol. 33. P. 42–55. doi: 10.1038/s41379-019-0394-6 |
| [19] |
Bichakjian CK, Lowe L, Lao CD, et al. Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management. Cancer. 2007;110(1):1–12. doi: 10.1002/cncr.22765 |
| [20] |
Bichakjian C.K., Lowe L., Lao C.D., et al. Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management // Cancer. 2007. Vol. 110, N 1. P. 1–12. doi: 10.1002/cncr.22765 |
| [21] |
Pulitzer M. Merkel cell carcinoma. Surg Pathol Clin. 2017;10(2):399–408. doi: 10.1016/j.path.2017.01.013 |
| [22] |
Pulitzer M. Merkel cell carcinoma // Surg Pathol Clin. 2017. Vol. 10, N 2. P. 399–408. doi: 10.1016/j.path.2017.01.013 |
| [23] |
Carneiro C, Juliano CS, Balchiero JC, et al. Merkel cell carcinoma: Clinical presentation, prognostic factors, treatment and survival in 32 patients. Rev Bras Cir Plástica. 2013;28(2):196–200. |
| [24] |
Carneiro C., Juliano C.S., Balchiero J.C., et al. Merkel cell carcinoma: Clinical presentation, prognostic factors, treatment and survival in 32 patients // Rev Bras Cir Plástica. 2013. Vol. 28, N 2. P. 196–200. |
| [25] |
Schmidt U, Muller U, Metz KA, et al. Cytokeratin and neurofilament protein staining in Merkel cell carcinoma of the small cell type and small cell carcinoma of the lung. Amer J Dermatopathol. 1998;20(4):346–351. doi: 10.1097/00000372-199808000-00004 |
| [26] |
Schmidt U., Muller U., Metz K.A., et al. Cytokeratin and neurofilament protein staining in Merkel cell carcinoma of the small cell type and small cell carcinoma of the lung // Amer J Dermatopathol. 1998. Vol. 20, N 4. P. 346–351. doi: 10.1097/00000372-199808000-00004 |
| [27] |
Iyer JG, Storer BE, Paulson KG, et al. Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma. J Am Acad Dermatol. 2014;70(4):637–643. doi: 10.1016/j.jaad.2013.11.031 |
| [28] |
Iyer J.G., Storer B.E., Paulson K.G., et al. Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma // J Am Acad Dermatol. 2014. Vol. 70, N 4. P. 637–643. doi: 10.1016/j.jaad.2013.11.031 |
| [29] |
Orlova KV, Oryol NF, Trofimova OP, Kostina NP, Demidov LV. Merkel cell carcinoma: current treatment options. Effektivnaya farmakoterapiya. 2016;39:88–93. EDN: XWUPEZ |
| [30] |
Орлова К.В., Орел Н.Ф., Трофимова О.П., Костина Н.П., Демидов Л.В. Карцинома Меркеля: современные возможности терапии // Эффективная фармакотерапия. 2016. Т. 39. С. 88–93. EDN: XWUPEZ |
| [31] |
Young S, Oh J, Bukhari H, et al. Primary parotid Merkel type small cell neuroendocrine carcinoma with oligometastasis to the brain and adrenal gland: case report and review of literature. Head Neck Pathol. 2021;15:311–318. doi: 10.1007/s12105-020-01164-w |
| [32] |
Young S., Oh J., Bukhari H., et al. Primary parotid Merkel type small cell neuroendocrine carcinoma with oligometastasis to the brain and adrenal gland: case report and review of literature // Head Neck Pathol. 2021. Vol. 15. P. 311–318. doi: 10.1007/s12105-020-01164-w |
| [33] |
Baek SH, Jung HK, Kim W, et al. Merkel cell carcinoma of the axilla and adrenal gland: a case report with imaging and pathologic findings. Case Rep Med. 2015;2015. doi: 10.1155/2015/931238 |
| [34] |
Baek S.H., Jung H.K., Kim W., et al. Merkel cell carcinoma of the axilla and adrenal gland: a case report with imaging and pathologic findings // Case Rep Med. 2015. Vol. 2015. doi: 10.1155/2015/931238 |
| [35] |
Alguraan Z, Agcaoglu O, Aliyev S, Berber E. A rare case of Merkel cell carcinoma metastasis to the adrenal resected robotically. Surg Laparosc Endosc Percutan Tech. 2013;23(1):e35–e37. doi: 10.1097/SLE.0b013e31827479a1 |
| [36] |
Alguraan Z., Agcaoglu O., Aliyev S., Berber E. A rare case of Merkel cell carcinoma metastasis to the adrenal resected robotically // Surg Laparosc Endosc Percutan Tech. 2013. Vol. 23, N 1. P. e35–e37. doi: 10.1097/SLE.0b013e31827479a1 |
Eco-Vector
/
| 〈 |
|
〉 |