Multidisciplinary approach to treatment of advanced gastric cancer
Elena V. Trusilova , N. S Besova , S. V Khokhlova , V. A Gorbunova , S. N Nered , I. S Stilidi
Russian Journal of Oncology ›› 2015, Vol. 20 ›› Issue (5) : 33 -36.
Multidisciplinary approach to treatment of advanced gastric cancer
This arcticle presents possibilities of combined treatment of a patient with advanced gastric cancer. The patient with gastric cancer and hepatic, paragastric and left supraclavicular metastases was treated by chemotherapy. 8 courses of chemotherapy by docetaxel + cisplatin + 5-fluorouracil + leucovorin resulted in complete regression of distant metastases. This allowed conducting D2 subtotal gastric resection in the patient. Morphologic examination of the tissue samples obtained during surgery identified a low-differetiated gastric adenocarcinoma infiltrating gastric wall to the subserous layer. No metastases were detected in locoregional lymph nodes. Adjuvant chemotherapy was discontinued after 2 courses because of increasing neuropathy. Over the follow up period no disease progression has been registered by April 2015. The overall survival reached 67 months. Thus, combined treatment of the patient resulted in increased overall survival.
advanced gastric cancer / combined therapy / chemotherapy
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