Level of certain serum hormones in experimental liver metastasis

Abstract

Studying tumor and metastasis biology is an important challenge of both biology and medicine, since only an experiment may reveal fine mechanisms of pathogenesis. We analyzed the dynamics of serum hormones in a model of rat liver metastates designed by our group, which excluded toxic carcinogen effects, sharp surgical influence and narcosis. The results showed that liver metastases were associated with the following: 1) hyperthyroidism developing at early stages of metastatic process was replaced by latent hypothyroidism after 5 weeks of the carcinogenesis as a result of autoimmune thyroiditis; 2) the increase of progesterone, LG and prolactin levels after 5 weeks of tumor metastasis in liver after the 2 weeks ’ initial decrease; 3) sexual hormones metabolism activation: after a week - increase offree testosterone level, after 2 weeks -rise of estrone and total testosterone and the decrease of estrogen levels after 5 weeks of carcinogenesis; 4) adrenal gland activation leading to the enhancement of serum stress hormone corticosterone and its antagonist DHEA.

Keywords

hormones / serum / metastasis / liver / rats

References

[1] Бондарь Г.В., Думанский Ю.В., Седаков И.Е., Ищенко Р.В. Внутриартериальная полихимиотерапия при колоректальном раке с метастазами в печени. Онкология. 2011; 13 (1): 37-9.

[2] Берштейн Л.М., Барук А.С., Гершфельд Э.Д. и др. Ароматаза и её ингибиторы при различных онкологических заболеваниях помимо рака молочной железы. Вопросы онкологии. 2007; 53 (1): 7-13.

[3] Кит О.И., Козлова М.Б., Франциянц Е.М., Никипелова Е.А. и др. Колоректальный рак и половые гормоны: содержание в крови больных с одиночным, рецидивным и первично-множественным процессом. Фундаментальные исследования. 2014; 7 (ч. 3): 517-21.

[4] Ковалев А.А., Ковалев К.А., Смирнов Л.Ю., Семенова Т.А., Колесник И.Ф., Котелевец Н.В., Рябошапка А.Н. Радиочастотная термоабляция в лечении метастатического рака печени. Сучаснi медичнi технологii. 2009; 1: 41-9.

[5] Федосов А.В., Семейкин А.В. Прогестины: молекулярные механизмы контроля пролиферации и апоптоза клеток чувствительных тканей. Вопросы онкологии. 2003; 49 (1): 9-20.

[6] Bigsby R.M., Caperell-Grant A. The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorogenesis. Carcinogenesis. 2011; 32 (8): 1162-6.

[7] Hilakivi-Clarke L.A., Arora P.K., Clarke R., Wright A., Lippman M.E., Dickson R.B. Opposing behavioural alterations in male and female transgenic TGF alpha mice: association with tumour susceptibility. Br. J. Cancer. 1993; 67 (5): 1026-30.

[8] Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA. Cancer J. Clin. 2011; 61 (2): 69-90.

[9] Matsumoto T., Takagi H., Mori M. Androgen dependency of hepatocarcinogenesis in TGFalpha transgenic mice. Liver. 2004; 24 (3): 275.

[10] Nordlinger B., Van Cutsem E., Rougier P., Kuhne C.H. et al. European Colorectal Metastases Treatment Group: Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastasis Treatment Group. Eur. J. Cancer. 2007; 43 (14): 2037-45.

[11] Wang W.W., Ang S.F., Kumar R., Heah C. et al. Identification of serum monocyte chemoattractant protein-1 and prolactin as potential tumor markers in hepatocellular carcinoma. PLoS One. 2013; 18 (8): 7.

RIGHTS & PERMISSIONS

Eco-Vector