Characteristics of lymphocyte subpopulations intratumoral ovarian cancer

Seda O. Nikoghosian; N. N Tupitsyn; A. V Mozhenkova; N. V Kokosadze; N. V Levitskaya; E. V Zueva; V. V Kuznetsov

doi:10.17816/onco40116

Russian Journal of Oncology ›› 2015, Vol. 20 ›› Issue (2) : 18 -21. DOI: 10.17816/onco40116

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Characteristics of lymphocyte subpopulations intratumoral ovarian cancer

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Abstract

The article presents some mechanisms of antitumor immunity, lymphocyte subpopulations present in tissues of serous ovarian cancer were studied (intratumoral lymphocytes). The composition of intratumoral lymphocytes in tumor stroma, depending on its degree of differentiation was studied. A significant relationship between the degree of infiltration of mature T cells and the degree of differentiation of serous ovarian cancer was revealed.

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serous ovarian cancer / intratumoral lymphocytes / flow cytometry

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Seda O. Nikoghosian, N. N Tupitsyn, A. V Mozhenkova, N. V Kokosadze, N. V Levitskaya, E. V Zueva, V. V Kuznetsov. Characteristics of lymphocyte subpopulations intratumoral ovarian cancer. Russian Journal of Oncology, 2015, 20(2): 18-21 DOI:10.17816/onco40116

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References

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[1]	Минимальные клинические рекомендации европейского общества медицинской онкологии (ESMO). М.; 2010: 33-49.

[2]	Каприн А.Д., Старинский В.В., Петрова Г.В., ред. Состояние онкологической помощи населению России в 2013 году. М.; 2014.

[3]	Matsushita N., Ghazizadeh M., Konishi H., Araki T. Association of ovarian tumor epithelium coexpressing HLA-DR and CA-125 antigens with tumor infiltrating cytotoxic T lymphocytes. J. Nippon Med. Sch. 2003; 70(1): 40-4.

[4]	Zang L., Conero-Garcia J. R., Katsaros D. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 2003; 348(3): 203-13.

[5]	Curiel T. J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004; 10: 942-9.

[6]	Sato E., Olson S. H., Ahn J. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cells ratio are associated with favorable prognosis in ovarian cancer. Proc. Natl. Acad. Sci. USA. 2005; 102(51): 18538-43.

[7]	Tupitsyn N. N., Kadagidze Z. G., Tuichev I. K. Relationship between semiquantitative and quantitative parameters of local immune response in gastric cancer. Exp. Oncol. 1995; 17(1): 31-6.

[8]	Kabawat S.E., Bast R.C.Jr., Welch W.R., Knapp R.C., Bhan A.K. Expression of major histocompatibility antigens and nature of inflammatory cellular infiltrate in ovarian neoplasms. Int. J. Cancer. 1983; 32(5): 547-54.

[9]	Thanaa El-A Helal, Ali Alla, Mohamed Laban, Remon Fahmy. Immunophenotyping of Tumor-infiltrating mononuclear cells in ovarian carcinoma. Pathol. Oncol. Res. 2007; 10 (2): 80-4.

[10]	Артамонова Е.В., Огнерубов Н.А., Тупицын Н.Н., Летягин В.П. Местные иммунные реакции при раке молочной железы. B кн.: Рак молочной железы: иммунологические факторы прогноза. Воронеж; 2005: 89-137.

[11]	Зуева Е.В. Клиническое значение иммунофенотипирования серозной аденокарциномы яичников: Дисс. … канд. мед. наук. М.; 2010.