FLUORESCENCE DIAGNOSIS AND PHOTODYNAMIC THERAPY OF MALIGNANT GLIOMAS IN RATS

I. Yu Kubasova; Z. S Smirnova; K. V Ermakova; L. M Borisova; M. P Kiseleva; N. A Oborotova; G. A Meerovich; V. M Derkacheva

doi:10.17816/onco39950

Russian Journal of Oncology ›› 2013, Vol. 18 ›› Issue (2) : 14 -18. DOI: 10.17816/onco39950

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FLUORESCENCE DIAGNOSIS AND PHOTODYNAMIC THERAPY OF MALIGNANT GLIOMAS IN RATS

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Abstract

The possibilities of fl uorescence diagnosis (FD) and photodynamic therapy (PDT) with domestic photosensitizers and domestic equipment in brain tumors have been studied. Investigation of the level and selectivity of accumulation dynamics of Photosens and Tiosens in C6 glioma tissue by spectral fl uorescence method has showed the selective accumulation of both agents in tumor tissue. High effi ciency of PDT with Photosens and Tiosens both as monotherapy and as combined treatment has been shown on the base of pathomorphological criteria. Increase of therapeutic effi cacy of combined treatment of C6 glioma using FD and intraoperative PDT with Alasens has been established.

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photodynamic therapy / fl uorescence diagnosis / glioma C6 / Photosens / Tiosens / Alasens

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I. Yu Kubasova, Z. S Smirnova, K. V Ermakova, L. M Borisova, M. P Kiseleva, N. A Oborotova, G. A Meerovich, V. M Derkacheva. FLUORESCENCE DIAGNOSIS AND PHOTODYNAMIC THERAPY OF MALIGNANT GLIOMAS IN RATS. Russian Journal of Oncology, 2013, 18(2): 14-18 DOI:10.17816/onco39950

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