IN VIVO PHOTO-INDUCED ACTIVITY OF POSITIVELY CHARGED ZINC PHTHALOCYANINE USED FOR PHOTODYNAMIC THERAPY FOR MALIGNANCIES

N. B. Morozova; R. I. Yakubovskaya; V. I. Chissov; V. M. Negrimovsky; O. A. Yuzhakova

doi:10.17816/onco39932

Russian Journal of Oncology ›› 2012, Vol. 17 ›› Issue (1) : 23 -28. DOI: 10.17816/onco39932

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IN VIVO PHOTO-INDUCED ACTIVITY OF POSITIVELY CHARGED ZINC PHTHALOCYANINE USED FOR PHOTODYNAMIC THERAPY FOR MALIGNANCIES

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Abstract

The substituted phthalocyanine complex cholosens was in vivo investigated as a photosensitizer used in photodynamic therapy (PDT) for malignancies. Cholosens immediately accumulates in the tissues of murine tumors (Lewis lung carcinoma (LLC), colon adenocarcinoma 26 (C26), sarcoma 37 (S37), and melanoma B16) imaged by fluorescence to show contrast of tumor compared to adjacent tissue from 2 to 4 conventional units. The maximum tumor fluorescence the λ тах = 696.5 nm is recorded 5-30 minutes after injection. Cholosens has a high photo-induced activity against tumors of different genesis. The use of effective PDT regimes (cholosens, 0.5-1.0 mg/kg; interval, At 5-30 min; energy density, 90-180 J/cm 2) yields high treatment results: tumor growth suppression is 81.8-98.6%; higher survival rates are 49.0-115.3%; recovery index is 25.0-66.7%. LLC, C26, and S37 are most susceptible to PDT with cholosens. The later is a promising photosensitizer used in PDT for malignancies and for antimicrobial PDT.

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photodynamic therapy / photosensitizer / cationic phthalocyanines / cholosens / local fluorescence spectroscopy / antitumor efficacy

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N. B. Morozova, R. I. Yakubovskaya, V. I. Chissov, V. M. Negrimovsky, O. A. Yuzhakova. IN VIVO PHOTO-INDUCED ACTIVITY OF POSITIVELY CHARGED ZINC PHTHALOCYANINE USED FOR PHOTODYNAMIC THERAPY FOR MALIGNANCIES. Russian Journal of Oncology, 2012, 17(1): 23-28 DOI:10.17816/onco39932

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