SERUM LEVELS OF TUMOR NECROSIS FACTOR (TNF-A) AND ITS SOLUBLE RECEPTORS STNF-R1 AND STNF-R2 IN CANCER PATIENTS
V. I. Chissov , N. S. Sergeyeva , N. V. Marshutina , E. V. Filonenko , M. P. Solokhina , E. V. Zenkina , P. A. N. A. Parilova
Russian Journal of Oncology ›› 2012, Vol. 17 ›› Issue (1) : 16 -20.
SERUM LEVELS OF TUMOR NECROSIS FACTOR (TNF-A) AND ITS SOLUBLE RECEPTORS STNF-R1 AND STNF-R2 IN CANCER PATIENTS
The paper presents the results of investigating the balance of the proinflammatory cytokine TNF-α and its soluble receptors in the sera of patients with different kinds of solid tumors. As compared with donors, the patients showed a shift in the serum level distribution of TNF-а and its soluble receptors sTNF-R1 and sTNF-R2 towards higher values. This shift was most pronounced in patients with gastric or colorectal cancer and least in those with squamous cell carcinoma of the head and neck. Lung cancer and melanoma were intermediate. In the cancer patients, the correlation was found to remain between the serum levels of TNF-α and its receptors, which was similar to that in the donors. However, a number of patients (with all tumor sites in question) were observed to have an imbalance between the serum levels of TNF-α and sTNF-R1 due to a greater proportion of cases with both a low and high sTNF-RUTNF-α ratio.
tumor necrosis factor / soluble receptors sTNF receptors types 1 and 2 / cancers / gastric cancer / colorectal cancer / squamous cell carcinoma of the head and neck / lung cancer / melanoma
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