COMPARATIVE ASSESSMENT OF VARIOUSLY FRACTIONATED CHEMORADIATION AND RADIATION THERAPY IN PATIENTS WITH CANCER OF THE ORAL AND OROPHARYNGEAL MUCOSA BY THE EFFECTIVENESS-TOXICITY CRITERION
M. U. Radzhapova , I. A. Gulidov , Yu. S. Mardynsky , D. Yu. Semin , V. S. Medvedev , I. N. Ivanova
Russian Journal of Oncology ›› 2012, Vol. 17 ›› Issue (1) : 4 -7.
COMPARATIVE ASSESSMENT OF VARIOUSLY FRACTIONATED CHEMORADIATION AND RADIATION THERAPY IN PATIENTS WITH CANCER OF THE ORAL AND OROPHARYNGEAL MUCOSA BY THE EFFECTIVENESS-TOXICITY CRITERION
Two hundred and thirty-three patients with primary cancer of the oral and otopharyngeal mucosa received chemoradiotherapy with unequal divisions of a daily dose and standard radiotherapy. After chemoradiotherapy with division of the dose of into 1 + 1.5 Gy and fractionation into 1 + 2 Gy, the rate of objective responses (a sum of complete and partial regressions) was significantly higher than that following standard radiotherapy (97.8, 100, and 61.9%, respectively). During chemoradiation therapy in the 1 + 1.5 Gy and 1 + 2 Gy regimen, the incidence of Grade 3 mucositis was 40.5 and 77.8% (p < 0.05) versus 52.7% of those receiving the standard radiotherapy. Late radiation damage to normal tissues and organs in a radiation area were observed in 8.9, 10.8, and 20.2% of cases, respectively (p > 0.05). In terms of the early toxic effect - mucosal radiation reactions, variously fractionated chemotherapy is fairly tolerated by patients and, after it, there is no increase in late local toxicity as compared to the standard radiotherapy.
objective response / effectiveness-toxicity / chemoradiotherapy / late radiation damages
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