Clinical aspects of the molecular genetic profile of uterine carcinosarcoma
N V Levitskaya , K M Pozharisskiy , O A Vostryukhina , L N Alekseeva , M V Nemtsova , I V Matrosova , I V Poddubnaya , N V Levitskaya , K M Pozharissky , O A Vostryukhina , L N Alekseyeva , M V Nemtsova , I V Matrosova , I V Poddubnaya
Russian Journal of Oncology ›› 2011, Vol. 16 ›› Issue (5) : 25 -29.
Clinical aspects of the molecular genetic profile of uterine carcinosarcoma
The paper gives the results of a molecular genetic study of tumor tissues from 13 patients with uterine carcinosarcoma. Having determined damages to genes (K-RAS exon 1, TP53 exons 5-9, PTEN exons 5 and 8) in the components of carcinosarcoma, the authors assessed each of the study parameters as a potentially clinical prognostic criterion. Whether aberrant TP53 and PTEN and tumor clonality could be used as clinical markers was confirmed.
PTEN / uterine carcinosarcoma / clonality / TP53 / PTEN
| [1] |
Имянитов Е. Н., Хансон К. П. // Молекулярная онкология: клинические аспекты. - СПб., 2007. - С. 148. |
| [2] |
Немцова М. В., Башкатов С. В., Корякин О. Б. и др. // Системы генетических и эпигенетических маркеров в диагностике онкологических заболеваний. - М., 2009. - С. 188- 215. |
| [3] |
Тимофеев А. В., Алексеева Л. Н., Мацко Д. Е. и др. // Вопр. онкол. - 2008. - Т. 54, № 1. - С. 47-52. |
| [4] |
Goelz S., Hamilton S., Vogelstein B. // Biochem. Biophys. Res. Commun. - 1985. - Vol. 130. - P. 118-126. |
| [5] |
Isobe M., Emmanual B. S., Givol D. // Nature. - 1986. - Vol. 320. - P. 84-85. |
| [6] |
Janiec-Jankowska A., Konopka B., Goluda C. et al. // Int. J. Gynecol. Cancer. - 2010. - Vol. 20, N 2. - P. 196-202. |
| [7] |
Jopp H., Krone H. // Arch. Gynaekol. - 1962. - Vol. 197, N 4. - P. 387-397. |
| [8] |
Kounelis S., Jones M. W., Papadaki H. et al. // Hum. Pathol. - 1998. - Vol. 29, N 1. - P. 82-87. |
| [9] |
McCluggage W. G. // J. Clin. Pathol. - 2002. - Vol. 55. - P. 321-325. |
| [10] |
Sreenan J. J., Hart W. R. // Am. J. Surg. Pathol. - 1995. - Vol. 19, N 6. - P. 666-674. |
| [11] |
Tavassoli A., Devilee P. Pathology and genetics of tumours of the breast and femal genital organs. - Lyon, 2003. - P. 245- 249. |
| [12] |
Wada H., Enomoto T., Fujita M. et al. // Cancer Res. - 1997. - Vol. 57. - P. 5379-5385. |
| [13] |
Zhu Y., Hoell P., Ahlmeyer B. et al. // Apoptosis. - 2006. - Vol. 11. - P. 197-207. |
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