Preclinical study of binary catalytic systems as radio/chemomodifiers
O A Bezborodova , E R Nemtsova , Yu B Venediktova , T N Andreeva , R I Yakubovskaya , A A Pankratov , V I Chissov , O A Bezborodova , E R Nemtsova , Yu B Venediktova , T N Andreyeva , R I Yakubovskaya , A A Pankratov , V I Chissov
Russian Journal of Oncology ›› 2011, Vol. 16 ›› Issue (4) : 33 -36.
Preclinical study of binary catalytic systems as radio/chemomodifiers
The investigators conducted a preclinical study of the antitumor efficacy of the combined use of an Oxycobalamin-lio (Ox-lio) + Efiter acid-based binary catalytic system (BCS) with radiation and chemoradiation therapy. The incorporation of the BCS Ox-lio + ascorbic acid (Aa), which was used as independent antitumor agents, into a chemoradiation therapy regimen, was shown to lead to biologically important tumor growth suppression throughout the observation and to promote the potentiated therapeutic effect of radiation/chemotherapy. The therapeutic effectiveness of the Ox-lio + Aa BCS used as a modifier is higher than the Efiter + Ac BCS, which seems to be due to its detoxifying activity. The findings suggest the expediency of a clinical trial of the Ox-lio + Ac BCS as a modifier of medical treatments in patients with malignancies.
binary catalytic system / Oxycobalamin-lio / Efiter / chemomodifier / radiomodifier
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