Migratsiya kletok i onkogenez

Abstract

Tumor spread is a sign of disease progression. This process is associated with the migration of tumor cells and the development of new blood vessels (neoangiogenesis). The review gives the basic migration markers and their role in oncogenesis. The changes in the properties of tumor cells underlie tumor metastasis and invasion, which is associated with an epithelial-mesenchymal transition process. Mitogenic factors are first produced by a tumor cell and then by its microenvironment. Its key point is the capacity of a tumor to respond to growth factors.

Keywords

cell migration / malignancies / molecular markers

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