Neoadjuvant chemotherapy using taxanes in the combination treatment of non-small cell lung cancer

S V Miller; S A Tuzikov; V E Gol'dberg; A A Zav'yalov; T V Polishchuk; A Yu Dobrodeev; E L Yumov; A F Lobykin; S V Miller; S A Tuzikov; V E Goldberg; A A Zavyalov; T V Polishchuk; A Yu Dobrodeyev; E L Yumov; A F Lobykin

doi:10.17816/onco39864

Russian Journal of Oncology ›› 2011, Vol. 16 ›› Issue (5) : 4 -8. DOI: 10.17816/onco39864

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Neoadjuvant chemotherapy using taxanes in the combination treatment of non-small cell lung cancer

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Abstract

The results of combination treatment with neoadjuvant chemotherapy using paclitaxel/carboplatin and docetaxel/cisplatin regimens, radical surgery, and 15-Gy intraoperative radiotherapy (IORT) were studied in 105 patients with stage III non-small cell lung cancer. Neoadjuvant chemotherapy resulted in a high immediate response rate (40.2 ± 5.7%). Chemotherapy response is directly correlated with tumor tissue involvement confirmed by histological examination. Preoperative systemic anti-tumor therapy showed a statistically significant increase in relapse-free and overall survivals in patients with locally advanced non-small cell lung cancer.

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non-small cell lung cancer / surgical treatment / chemotherapy / intraoperative radiation

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S V Miller, S A Tuzikov, V E Gol'dberg, A A Zav'yalov, T V Polishchuk, A Yu Dobrodeev, E L Yumov, A F Lobykin, S V Miller, S A Tuzikov, V E Goldberg, A A Zavyalov, T V Polishchuk, A Yu Dobrodeyev, E L Yumov, A F Lobykin. Neoadjuvant chemotherapy using taxanes in the combination treatment of non-small cell lung cancer. Russian Journal of Oncology, 2011, 16(5): 4-8 DOI:10.17816/onco39864

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