Her-2/neu oncogene in gastric cancer: a clinical and laboratory study
V Yu Skoropad , N A Gorban' , G F Mikhaylova , A V Sevan'kaev , T A Khudyakova , V V Tsepenko , B A Berdov , V Yu Skoropad , N A Gorban , G F Mikhailova , A V Sevankayev , T A Khudyakova , V V Tsepenko , B A Berdov
Russian Journal of Oncology ›› 2011, Vol. 16 ›› Issue (2) : 22 -25.
Her-2/neu oncogene in gastric cancer: a clinical and laboratory study
The study was based on the examination of tumors in 31 patients radically operated on for locally advanced gastric cancer at the Medical Radiology Research Center, Russian Academy of Medical Sciences, in 2000-2007. The pilot study indicated rather high rates of Her-2/neu hyperexpression and amplification. It was shown that immunohistochemical and FISH assays used in breast cancer might be successfully used in gastric cancer. Analysis demonstrated that Her-2/neu hyperexpression/amplification in patients with gastric cancer was an important factor of poor prognosis. The authors suggested for the first time that Her-2/neu might be considered as one of the determinants of the mechanisms of metastasis in patients with gastric cancer.
gastric cancer / Her2/neu oncogene / surgical treatment / recurrences and metastases
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