Otsenka obshchetoksicheskikh svoystv preparata geksasens v eksperimente
A A Pankratov , Yu B Venediktova , T A Andreeva , R I Yakubovskaya , N T Raykhlin
Russian Journal of Oncology ›› 2010, Vol. 15 ›› Issue (3) : 19 -21.
Otsenka obshchetoksicheskikh svoystv preparata geksasens v eksperimente
The systemic toxic and local irritant effects of the new drug Hexasens used for the fluorescence diagnosis of malignancies were studied on small laboratory animals: mice, rats, and rabbits. The acute and chronic toxicities of the agent were investigated when orally used and its local irritant effect was examined when intravesicularly injected. The conducted studies indicated that Hexasens was a lowly toxic pharmacological agent. Its oral administration in rats at a 5% concentration or less produced no local irritant effect on the esophagus (esophagospasm). Intravesicular injection of Hexasens in rabbits at a 0.01% concentration (containing 1.0 mg of the agent in 10 ml of an injectable solution) or less exerted no local irritant effect on the urinary bladder mucosa.
5-aminolevulinic acid hexyl ester / hexasens / systemic toxic effect / local irritant effect
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